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High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.
CONCLUSION: The functional inhibition between Parp1 and Sirt1 leads to HMGB1 hyperacetylation, which leads to its translocation from the nucleus to the cytoplasm and finally outside the cell. PMID: 31576091 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 27, 2019 Category: Gastroenterology Authors: Ye TJ, Lu YL, Yan XF, Hu XD, Wang XL Tags: World J Gastroenterol Source Type: research

CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.
CONCLUSION: CacyBP/SIP nuclear translocation contributes to the proliferation of GC cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1. PMID: 27099442 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 20, 2016 Category: Gastroenterology Authors: Niu YL, Li YJ, Wang JB, Lu YY, Liu ZX, Feng SS, Hu JG, Zhai HH Tags: World J Gastroenterol Source Type: research

New role and molecular mechanism of Gadd45a in hepatic fibrosis.
CONCLUSION: Gadd45a may counteract hepatic fibrosis by regulating the activation of HSCs via the inhibition of TGF-β/Smad signaling. PMID: 26973416 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - March 7, 2016 Category: Gastroenterology Authors: Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG Tags: World J Gastroenterol Source Type: research

CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.
CONCLUSION: CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells. PMID: 25110433 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - August 7, 2014 Category: Gastroenterology Authors: Zhai HH, Meng J, Wang JB, Liu ZX, Li YF, Feng SS Tags: World J Gastroenterol Source Type: research