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Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor
Neurochem Res. 2021 Apr 5. doi: 10.1007/s11064-021-03303-3. Online ahead of print.ABSTRACTNeuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in metabolism diseases. However, little research has been focused on the effect of GAA in neuroinflammation and the related mechanism. In the present study, lipopolysaccharide(LPS)-stimulated BV2 microglial cells were used to eva...
Source: Neurochemical Research - April 6, 2021 Category: Neuroscience Authors: Yue Jia Dandan Zhang Hua Yin Haoran Li Jing Du Hongkun Bao Source Type: research