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Source: Neurochemical Research
Countries: China Health
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Total 1 results found since Jan 2013.
Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway
In this study, mouse hippocampal HT-22 cells were treated with ferric ammonium citrate (FAC) alone or together with IRN, and we found IRN reduced the FAC-induced cell damage. Then, cells were treated with IRN following treatment with FAC after transfection with miR-122-5p inhibitor, and the results showed IRN reduced the FAC-induced decrease of miR-122-5p levels and relieved the ferroptosis by detecting ferroptotic marker proteins, iron ion concentration and oxidative stress level; after transfection with miR-122-5p inhibitor, the protective effects of IRN against FAC-induced ferroptosis in these cells were weakened. TP53 ...
Source: Neurochemical Research - May 4, 2021 Category: Neuroscience Authors: Haikang Zhao Xiaoqiang Li Lei Yang Liang Zhang Xiaobing Jiang Wenwen Gao Peng Chen Yingying Cheng Fenglu Wang Jianrong Liu Source Type: research
