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Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis.
Abstract Recently we discovered a cDNA in teleost ovarian follicle cells belonging to the zinc transporter ZIP9 subfamily encoding a protein with characteristics of a membrane androgen receptor (mAR). Here we demonstrate that human ZIP9 expressed in MDA-MB-468 breast cancer cells and stably over-expressed in human prostate cancer PC-3 cells (PC-3-ZIP9) also displays the ligand binding and signaling characteristics of a specific, high-affinity mAR. Testosterone treatment of MDA-MB-468 and PC-3-ZIP9 cells caused activation of G proteins and second messenger pathways as well as increases in intracellular free zinc co...
Source: Endocrinology - July 11, 2014 Category: Endocrinology Authors: Thomas P, Dong J, Berg AH, Pang Y Tags: Endocrinology Source Type: research

Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female Atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells.
We report here cloning and expression of a cDNA from Atlantic croaker (Micropogonias undulatus) ovaries encoding a 33 kDa, 7-transmembrane protein with binding and signaling characteristics of a membrane androgen receptor (mAR) that is unrelated to any previously described steroid receptor. Instead croaker mAR has 81-93% amino acid sequence identity with zinc transporter ZIP9 (SLC39A9) subfamily members, indicating it is a ZIP9 protein. Croaker ZIP9 is expressed in gonadal tissues and in brain, and is upregulated in the ovary by reproductive hormones. ZIP9 protein is localized to plasma membranes of croaker granulosa cells...
Source: Endocrinology - July 11, 2014 Category: Endocrinology Authors: Berg AH, Rice CD, Rahman MS, Dong J, Thomas P Tags: Endocrinology Source Type: research