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Source: Biomaterials
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Total 61 results found since Jan 2013.
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research
Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation
This study provides a sophisticated method for HSC-targeting cytoplasmic RNA delivery using endogenous ligand hijacking and dual sensitivity of ROS and cis diol compounds.PMID:37167895 | DOI:10.1016/j.biomaterials.2023.122134
Source: Biomaterials - May 11, 2023 Category: Materials Science Authors: Jinsheng Huang Huiling Huang Yiyao Wang Bin Xu Minzhao Lin Shisong Han Yuanyuan Yuan Yong Wang Xintao Shuai Source Type: research
Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer
This study uncovered the critical role of ASPN in causing OXA resistance in CRC patients and suggests a promising nanoformulation that may be more effective than current standard-of-care medications.PMID:36228517 | DOI:10.1016/j.biomaterials.2022.121827
Source: Biomaterials - October 13, 2022 Category: Materials Science Authors: Cheng-Zhi Huang Yue Zhou Qi-Song Tong Qi-Jia Duan Qing Zhang Jin-Zhi Du Xue-Qing Yao Source Type: research
Ru(II)-modified TiO < sub > 2 < /sub > nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma
Biomaterials. 2022 Aug 24;289:121757. doi: 10.1016/j.biomaterials.2022.121757. Online ahead of print.ABSTRACTThe alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@Ru@siRNA is constructed from a ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA of hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, TiO2@Ru@siRNA can elicit both Type I and Type II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, and O...
Source: Biomaterials - September 4, 2022 Category: Materials Science Authors: Jia-Ying Zhou Wen-Jin Wang Chen-Yu Zhang Yu-Yi Ling Xiao-Jing Hong Qiao Su Wu-Guo Li Zong-Wan Mao Bin Cheng Cai-Ping Tan Tong Wu Source Type: research
Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy
In this study, it was proved that SerpinB9 (Sb9) downregulation can enhance the GrB susceptibility of tumor cells. Moreover, a nanocarrier fused with M1 macrophage exosomes (M1 Exo) and photothermal sensitive liposomes was constructed to efficiently transport GrB and siRNA of Sb9 to the cells. The nanocarrier is characterized by cascade tumor targeting acquired by photothermal effect-triggered increased expression of vascular cell adhesion molecule-1 (VCAM-1) in tumor tissue. Furthermore, the innate cytokines in M1 Exo are capable of regulating the tumor microenvironment by repolarizing M2 macrophages to the M1 type. Colle...
Source: Biomaterials - August 13, 2022 Category: Materials Science Authors: Ran Han Luting Yu Chenxuan Zhao Ying Li Yuying Ma Yuewen Zhai Zhiyu Qian Yueqing Gu Siwen Li Source Type: research
An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy
Biomaterials. 2022 Jun 22;287:121645. doi: 10.1016/j.biomaterials.2022.121645. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a high mortality rate. Immunotherapy has achieved promising clinical results in multiple cancers, but shows unsatisfactory outcome in GBM patients, and poor drug delivery across the blood-brain barrier (BBB) is believed to be one of the main limitations that hinder the therapeutic efficacy of drugs. Herein, a new cationic lipid nanoparticle (LNP) that can efficiently deliver siRNA across BBB and target mouse brain is prepared fo...
Source: Biomaterials - July 2, 2022 Category: Materials Science Authors: Shuhan Liu Ji Liu Haisong Li Kuirong Mao Haorui Wang Xiandi Meng Jialiang Wang Chenxi Wu Hongmei Chen Xin Wang Xiuxiu Cong Yue Hou Ye Wang Ming Wang Yong-Guang Yang Tianmeng Sun Source Type: research
Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
Biomaterials. 2022 May 2;285:121562. doi: 10.1016/j.biomaterials.2022.121562. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is characterized by a sudden decrease in renal function and impacts growing number of people worldwide. RNA interference (RNAi) showed potential to treat diseases with no or limited conventional therapies, including AKI. Suitable carriers are needed to protect and selectively deliver RNAi to target cells to fully explore this therapeutic modality. Here, we report on the synthesis of chitosan modified with α-cyclam-p-toluic acid (C-CS) as a novel siRNA carrier for targeted delivery to injure...
Source: Biomaterials - May 13, 2022 Category: Materials Science Authors: Weimin Tang Sudipta Panja Chinmay M Jogdeo Siyuan Tang Ling Ding Ao Yu Kirk W Foster Del L Dsouza Yashpal S Chhonker Heather Jensen-Smith Hee-Seong Jang Erika I Boesen Daryl J Murry Babu Padanilam David Oupick ý Source Type: research
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment
In this study, we successfully constructed a programmed site-specific delivery nanosystem for the combined delivery of transforming growth factor beta (TGF-β) receptor inhibitor LY3200882 (LY) and PD-L1 siRNA (siPD-L1) to boost anti-tumor immunotherapy. As expected, LY in the outer layer of the nanosystem was released by stimulation of MMP2, and dramatically down-regulated the expression of extracellular matrix (ECM) in the tumor-associated fibroblasts (TAFs), and thus promoted the infiltration of effector T cells and penetration of nanomedicines. Simultaneously, the blockade of TGF-β by LY also triggered immunogenic cel...
Source: Biomaterials - April 24, 2022 Category: Materials Science Authors: Pan Zhang Chao Qin Nan Liu Xinyuan Zhou Xuxin Chu Fangnan Lv Yongwei Gu Lifang Yin Jiyong Liu Jianping Zhou Meirong Huo Source Type: research
SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy
Biomaterials. 2021 Dec 30;281:121359. doi: 10.1016/j.biomaterials.2021.121359. Online ahead of print.ABSTRACTThe near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover, delivering them across the blood brain/tumor barrier (BBB/BTB) is further challenging to sought anticancer effect. To address these key challenges, we designed a linearly aligned nucleic acid-complexed polydixylitol-based polymeric nanochains (X-NCs), with inherent hyperosmotic properties enabling transmigration of th...
Source: Biomaterials - January 8, 2022 Category: Materials Science Authors: Shambhavi Pandey Myung Chul Lee Jae Woon Lim Yun-Hoon Choung Kyoung-Je Jang Sang Bae Park Jae Eun Kim Jong Hoon Chung Pankaj Garg Source Type: research
