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Source: Biomaterials
Countries: Jordan Health
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Total 2 results found since Jan 2013.
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
Biomaterials. 2023 Mar 28;297:122098. doi: 10.1016/j.biomaterials.2023.122098. Online ahead of print.ABSTRACTGene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized for inhibition of tumor driver genes. Ternary si-NPs containing siRNA, a single block NP core-forming polymer poly[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)] (DMAEMA-co-BMA, 50B), and an NP surface-forming diblock polymer 20 kDa poly(ethylene glycol)-block-50B (20kPEG-50B) have the potential to improve silencing activity in tumors due to the participation of both 50B and 20kPEG-50B in siRNA electrostatic...
Source: Biomaterials - April 9, 2023 Category: Materials Science Authors: Shrusti S Patel Ella N Hoogenboezem Fang Yu Carlisle R DeJulius R Brock Fletcher Alex G Sorets Fiona K Cherry Justin H Lo Mariah G Bezold Nora Francini Richard d'Arcy Jordan E Brasuell Rebecca S Cook Craig L Duvall Source Type: research
