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Source: Biomacromolecules

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Total 92 results found since Jan 2013.

Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells
Biomacromolecules. 2022 Apr 1. doi: 10.1021/acs.biomac.1c01497. Online ahead of print.ABSTRACTTo date, the application of RNA therapeutics to hematologic malignancies has been challenging owing to the resistance of blood cancer cells against conventional transfection methods. Herein, triple-targeting moiety-functionalized polymeric small interfering RNA (siRNA) nanoparticles were systematically developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. Polymeric siRNAs were synthesized using rolling circle transcription and were surface-functionalized with three types of targeting moieties...
Source: Biomacromolecules - April 1, 2022 Category: Biochemistry Authors: Eunji Kwak Taehyung Kim Kyungjik Yang Young Min Kim Hwa Seung Han Kyung Hoon Park Ki Young Choi Young Hoon Roh Source Type: research

Impact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability.
Abstract RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or morpholino functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups), of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5 was...
Source: Biomacromolecules - January 20, 2015 Category: Biochemistry Authors: Frère A, Kawalec M, Tempelaar S, Peixoto P, Hendrick E, Peulen O, Evrard B, Dubois P, Mespouille L, Mottet D, Piel G Tags: Biomacromolecules Source Type: research

Triblock copolymer nanovesicles for pH-responsive targeted delivery and controlled release of siRNA to cancer cells.
Abstract New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and poly-glycerolmethacrylate (poly-GMA), and a central weakly-basic block, poly-imidazole-hexyl methacrylate (poly-ImHeMA), which can complex with oligonucleotides and control vesicle formation/disassembly via pH variations. Targeted polymersomes were prepared by mixing folate-derivatised and underivatised copolymers. At pH 5, ds-DNA was found to complex with the pH-responsive copolymers at a N/P molar ratio above ~2...
Source: Biomacromolecules - May 19, 2015 Category: Biochemistry Authors: Gallon E, Matini T, Sasso L, Mantovani G, Armiñan de Benito A, Sanchis J, Caliceti P, Alexander C, Vicent MJ, Salmaso S Tags: Biomacromolecules Source Type: research

Correction to Fine Tuning of Core-Shell Structure of Hyaluronic Acid/Cell-Penetrating Peptides/siRNA Nanoparticles for Enhanced Gene Delivery to Macrophages in Antiatherosclerotic Therapy.
PMID: 30058804 [PubMed - as supplied by publisher]
Source: Biomacromolecules - July 30, 2018 Category: Biochemistry Authors: Zhao Y, He Z, Gao H, Tang H, He J, Guo Q, Zhang W, Liu J Tags: Biomacromolecules Source Type: research

Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo.
Abstract Efficient delivery of small interfering RNA (siRNA) is one of major challenges in the successful applications of siRNA in clinic. In the present study, we report a new acid-degradable poly(ketal amidoamine) (PKAA) as a siRNA carrier, which has high delivery efficiency and low cytotoxicity. PKAA was designed to have acid-cleavable ketal linkages in the backbone of cationic biodegradable poly(amidoamine). PKAA efficiently self-assembled with siRNA to form nanocomplexes with a diameter of 200 nm and slightly positive charges, which are stable under physiological conditions, but rapidly release siRNA at ac...
Source: Biomacromolecules - December 16, 2012 Category: Biochemistry Authors: Lim H, Noh J, Kim Y, Kim H, Kim J, Khang G, Lee D Tags: Biomacromolecules Source Type: research

Assessment of Cholesterol-Derived Ionic Copolymers as Potential Vectors for Gene Delivery.
Abstract A library of cholesterol-derived ionic copolymers were synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization as 'smart' gene delivery vehicles holding diverse surface charges. Polyplex systems formed with anionic poly(methacrylic acid-co-cholesteryl methacrylate P(MAA-co-CMA) and cationic poly(dimethylamino ethyl methacrylate-co-cholesteryl methacrylate Q-P(DMAEMA-co-CMA) copolymer series were evaluated for their therapeutic efficiency. Cell viability assays, conducted on SHEP, HepG2, H460 and MRC5 cell lines, revealed that alterations in the copolymer composition (CMA mol...
Source: Biomacromolecules - October 14, 2013 Category: Biochemistry Authors: Sevimli S, Sagnella SM, Kavallaris M, Bulmus V, Davis TP Tags: Biomacromolecules Source Type: research

A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo.
Abstract Pancreatic cancer is a devastating disease with a dismal prognosis. Short-interfering RNA (siRNA) based therapeutics hold promise for the treatment of cancer. However, development of efficient and safe delivery vehicles for siRNA remains a challenge. Here, we describe the synthesis and physicochemical characterization of star polymers (star 1, star 2, star 3) using reversible addition-fragmentation chain transfer polymerization (RAFT) for the delivery of siRNA to pancreatic cancer cells. These star polymers were designed to contain different lengths of cationic poly(dimethylaminoethyl methacrylate) (PDMAE...
Source: Biomacromolecules - June 14, 2016 Category: Biochemistry Authors: Teo J, McCarroll JA, Boyer C, Youkhana J, Sagnella SM, Duong HT, Liu J, Sharbeen G, Goldstein D, Davis TP, Kavallaris M, Phillips PA Tags: Biomacromolecules Source Type: research

Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery.
Abstract A new family of cationic dendron-bearing lipids (CDLs) with poly(amidoamine) dendrons of first to third generation (named as A1, A2 and A3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. All the CDLs could effectively bind small interfering RNA (siRNA) to form complexes confirmed by gel retardation analysis. In in vitro transfection experiments, A1/siRNA complexes exhibited significant gene silencing efficiency close to LipofectamineTM 2000/siRNA complexes and much higher than A2/siRNA and A3/siRNA complexes. To reveal the underlying reason...
Source: Biomacromolecules - October 21, 2013 Category: Biochemistry Authors: Zhang Y, Chen J, Xiao C, Li M, Tian H, Chen X Tags: Biomacromolecules Source Type: research

Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)- < em > b < /em > -poly(l-lysine)
This study revealed that the uPIC formation between siRNA and bPEG-PLys can be controlled by their charges, which may be helpful for designing PIC-based delivery systems.PMID:34935361 | DOI:10.1021/acs.biomac.1c01344
Source: Biomacromolecules - December 22, 2021 Category: Biochemistry Authors: Hiroyuki Chaya Mitsuru Naito Masaru Cho Kazuko Toh Kotaro Hayashi Shigeto Fukushima Yuichi Yamasaki Kazunori Kataoka Kanjiro Miyata Source Type: research

Anti-inflammatory effect of anti-tnf- α cationic phosphorous dendrimers nanocomplexes administered intranasally in a murine acute lung injury model.
ANTI-INFLAMMATORY EFFECT OF ANTI-TNF-α CATIONIC PHOSPHOROUS DENDRIMERS NANOCOMPLEXES ADMINISTERED INTRANASALLY IN A MURINE ACUTE LUNG INJURY MODEL. Biomacromolecules. 2017 Jun 22;: Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Abstract Inflammation is an essential component of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD) or acute lung injury. Our purpose was to design efficient carriers for lung delivery of small interfering RNA (siRNA) targeting tumor necrosis factor (TNF-α) in an...
Source: Biomacromolecules - June 22, 2017 Category: Biochemistry Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Tags: Biomacromolecules Source Type: research

Aqueous-soluble, acid-transforming chitosan for efficient and stimuli-responsive gene silencing.
This study demonstrates a molecularly engineered natural polymer for a biomedical application. PMID: 29562124 [PubMed - as supplied by publisher]
Source: Biomacromolecules - March 21, 2018 Category: Biochemistry Authors: Edson JA, Ingato D, Wu S, Lee B, Kwon YJ Tags: Biomacromolecules Source Type: research

Caged siRNAs with single cRGD modification for photo-regulation of exogenous and endogenous gene expression in cells and mice.
This study also suggested that photomodulation of target gene expression using single cRGD caged siRNA at 5' end of antisense strand RNA inhibited siRNA activity probably due to three factors: 1) trapping of cRGD modified siRNA in endosome and lysosome, 2) the steric hindrance of cRGD, 3) the binding of cRGD to its corresponding receptor. PMID: 29727579 [PubMed - as supplied by publisher]
Source: Biomacromolecules - May 4, 2018 Category: Biochemistry Authors: Yu L, Liang D, Chen C, Tang X Tags: Biomacromolecules Source Type: research

ATP-responsive low-molecular-weight polyethylenimine-based supramolecular assembly via host-guest interaction for gene delivery.
Abstract In this work, we report on an ATP-responsive low-molecular-weight polyethylenimine (LMW-PEI)-based supramolecular assembly. It formed via host-guest interaction between PEI (MW=1.8 kDa)-α-cyclodextrin (α-CD) conjugates and PEI1.8k-phenylboronic acid (PBA) conjugates. The host-guest interaction between PEI1.8k-α-CD and PEI1.8k-PBA was confirmed by the 2D-NOESY chromatogram experiment and competition test. The ATP-responsive property of the supramolecular assembly was evaluated by a series of ATP-triggered degradation and siRNA release studies in terms of fluorescence resonance energy transfer, agarose g...
Source: Biomacromolecules - December 5, 2018 Category: Biochemistry Authors: Jiang C, Qi Z, Jia H, Huang Y, Wang Y, Zhang W, Wu Z, Yang H, Liu J Tags: Biomacromolecules Source Type: research

Tumor Chemosensitization through Oncogene Knockdown Mediated by Unique α-Tocopherylated Cationic Geminis.
Abstract Herein, siRNA transfection efficiency of a unique set of α-tocopherylated gemini lipids has been established in vitro and in vivo. High efficacy of oncogene silencing achieved using the biomacromolecular assembly, formed from siRNA complexes of co-liposomes containing an α-tocopherylated gemini lipid, has been utilized for tumor regression via chemosensitization. Delivery studies with the gemini bearing hydroxyethyl headgroup with octamethylene spacer (TH8S) pointed to a higher siRNA transfection efficacy than its analog without hydroxyethyl group (T8S). Owing to p53 upregulation, transfected cells show...
Source: Biomacromolecules - March 24, 2019 Category: Biochemistry Authors: Kamra M, Maiti B, Dixit A, Karande AA, Bhattacharya S Tags: Biomacromolecules Source Type: research