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Source: Biology of Reproduction
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Total 100 results found since Jan 2013.
HOXA10 improves endometrial receptivity by upregulating E-cadherin
In conclusion, HOXA10 can bind to the E-cadherin promoter region and directly regulate its expression, thereby improving endometrial receptivity and subsequently increasing the embryo adhesion and implantation.PMID:35044439 | DOI:10.1093/biolre/ioac007
Source: Biology of Reproduction - January 19, 2022 Category: Reproduction Medicine Authors: Yin Bi Weiyu Huang Lifang Yuan Saiqiong Chen Shengbin Liao Xiaoqian Fu Bo Liu Yihua Yang Source Type: research
The Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
Biol Reprod. 2022 Jan 29:ioac020. doi: 10.1093/biolre/ioac020. Online ahead of print.ABSTRACTAs a critical paracrine regulator of multiple reproductive functions, the cytokine interleukin-6 (IL-6) is expressed in human granulosa cells and can be detected in follicular fluid. At present, the functional role of IL-6 in the regulation of ovarian steroidogenesis is controversial. Moreover, the detailed molecular mechanisms by which IL-6 regulates the production of progesterone in human granulosa cells remain to be elucidated. In the present study, we used primary and immortalized human granulosa-lutein (hGL) cells to investiga...
Source: Biology of Reproduction - January 31, 2022 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jeremy H Wang Jing Yang Peter C K Leung Source Type: research
Activin a promotes hyaluronan production and upregulates versican expression in human granulosa cells via the ALK4-SMAD2/3-SMAD4 signaling pathway
Biol Reprod. 2022 Apr 9:ioac070. doi: 10.1093/biolre/ioac070. Online ahead of print.ABSTRACTHyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and is critical for successful ovulation. Activin A is a critical intrafollicular regulator of ovarian function. Although activin A has been shown to promote cumulus matrix expansion in mice, the functional role of activin A in the regulation of cumulus expansion in the human ovary remains to be elucidated....
Source: Biology of Reproduction - April 11, 2022 Category: Reproduction Medicine Authors: Shen Tian Han Zhang Hsun-Ming Chang Christian Klausen He-Feng Huang Min Jin Peter C K Leung Source Type: research
Associations between isoflavone exposure and reproductive damage in adult males: evidence from human and model system studies
This study was designed to investigate whether isoflavone exposure during adulthood could have deleterious impacts on male reproductive health by the cross-sectional study, animal experiments, and in vitro tests. In the cross-sectional study, we observed that urinary isoflavones were not significantly associated with semen quality including sperm concentrations, sperm count, progressive motility, and total motility, respectively (All P-value for trend>0.05). However, negative associations were found between plasma testosterone and urinary Σisoflavones, genistein, glycitein, and dihydrodaidzein (all P-value for trend &l...
Source: Biology of Reproduction - August 10, 2022 Category: Reproduction Medicine Authors: Wang Yang Jiuyang Deng Jianfang Gao Huan Yang Qing Chen Zhou Niya Xi Ling Guowei Zhang Peng Zou Lei Sun Linping Huang Jinyi Liu Jia Cao Lin Ao Source Type: research
HIF-1 α is Essential for the Augmentation of Myometrial Contractility during Labor
In this study, transcriptomes revealed that hypoxia-inducible factor (HIF)-1α was up-regulated in laboring myometrial biopsies, while blockade of HIF-1α decreased the contractility of the myometrium and myocytes in vitro via siRNA and the inhibitor, 2-methoxyestradiol. Chromatin immunoprecipitation sequencing revealed that HIF-1α directly binds to the genome of contraction-associated proteins: the promoter of GJA1 and PTGS2, and the intron of OXTR. Silencing the HIF-1α reduced the expression of PTGS2, GJA1, and OXTR. Furthermore, blockade of GJA1 or PTGS2 led to a significant decrease in myometrial contractions in the ...
Source: Biology of Reproduction - September 12, 2022 Category: Reproduction Medicine Authors: Bolun Wen Zheng Zheng Lele Wang Xueya Qian Xiaodi Wang Yunshan Chen Junjie Bao Yanmin Jiang J I Kaiyuan Huishu Liu Source Type: research
Sialyl Lewis X mediates interleukin-1 beta induced trophoblast adhesion to endometrial cells during human embryo implantation
Biol Reprod. 2023 Jan 16:ioad007. doi: 10.1093/biolre/ioad007. Online ahead of print.ABSTRACTCell surface carbohydrate antigens sialyl Lewis X (sLeX) and Lewis Y (LeY) are paramount glycoconjugates and are abundantly expressed in the receptive endometrium. Furthermore, among the important biological functions of both antigens is their role in leukocytes adhesion and extravasation. Interleukin-1 beta (IL-1β) is involved in the process of human embryo implantation and placenta development. Here we used an in vitro model to investigate whether sLeX and LeY are playing a role in the embryo implantation process mediated by IL-...
Source: Biology of Reproduction - January 17, 2023 Category: Reproduction Medicine Authors: Zhi Ma Mirjana Kessler Anca Chelariu-Raicu Markus Sperandio Sven Mahner Udo Jeschke Viktoria von Sch önfeldt Source Type: research
