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Source: Biology of Reproduction
Condition: Cholesterol
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Total 1 results found since Jan 2013.
The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells.
In this study, we found that NR2F2 is expressed in the nucleus of some peritubular myoid cells and in interstitial cells, mainly in steroidogenically active adult Leydig cells. In MA-10 and MLTC-1 Leydig cells, siRNA-mediated NR2F2 knockdown reduces basal steroid production without affecting hormone responsiveness. Consistent with this, we found that STAR mRNA and protein levels were reduced in NR2F2-depleted MA-10 and MLTC-1 cells. Transient transfections of Leydig cells revealed that a -986 bp mouse Star promoter construct was activated 3 fold by NR2F2. Using 5' progressive deletion constructs, we mapped the NR2F2-respon...
Source: Biology of Reproduction - June 4, 2014 Category: Reproduction Medicine Authors: Mendoza-Villarroel RE, Robert NM, Martin LJ, Brousseau C, Tremblay JJ Tags: Biol Reprod Source Type: research
