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LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE
Am J Physiol Lung Cell Mol Physiol. 2021 Aug 18. doi: 10.1152/ajplung.00138.2021. Online ahead of print.ABSTRACTThe receptor for advanced glycation end-products (RAGE) has been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, it is still unknown whether RAGE directly contributes to alveolar epithelial damage and abnormal repair responses. We hypothesize that RAGE activation not only induces lung tissue damage but also hampers alveolar epithelial repair responses. The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 18, 2021 Category: Cytology Authors: Simon D Pouwels Laura Hesse Xinhui Wu Venkata Sita Rama Raju Allam Daan van Oldeniel Linsey J Bhiekharie Simon Phipps Brian G G Oliver Reinoud Gosens Maria Sukkar Irene H Heijink Source Type: research

Store-operated Calcium Entry-associated Regulatory Factor Regulates Airway Inflammation and Airway Remodeling in Asthma Mice Models
CONCLUSIONS: SARAF plays a protective role against airway inflammation and remodeling in asthma mice models by blunting SOCE; SARAF may also be a functional regulating factor of hASMCs.PMID:34231388 | DOI:10.1152/ajplung.00079.2020
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 7, 2021 Category: Cytology Authors: Yi-Min Wang Wen-Juan Xu Lin-Li Xiang Mei Ding Jin-Jin Zhang Jing-Ya Lu Bao-Juan Xie Ya-Dong Gao Source Type: research

Passive siRNA transfection method for gene knockdown in air-liquid interface airway epithelial cell cultures
Am J Physiol Lung Cell Mol Physiol. 2021 May 26. doi: 10.1152/ajplung.00122.2021. Online ahead of print.ABSTRACTDifferentiation of human bronchial epithelial cells (HBEs) in air-liquid interface (ALI) cultures recapitulates organotypic modeling of the in vivo environment. Although ALI cultures are invaluable for studying the respiratory epithelial barrier, loss-of-function studies are limited by potentially cytotoxic reagents in classical transfection methods, the length of the differentiation protocol, and the number of primary epithelial cell passages. Here, we present the efficacy and utility of a simple method for siRN...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 26, 2021 Category: Cytology Authors: Colleen M Bartman Kimberly E Stelzig David R Linden Y S Prakash Sergio E Chiarella Source Type: research

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