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Source: Journal of Southern Medical University
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Total 774 results found since Jan 2013.
Chitosan/PIK3CA siRNA nanoparticle-mediated PIK3CA gene interference decreases the invasive capacity of gastric cancer cells in vitro.
CONCLUSION: PIK3CA gene interference mediated by PIK3CA/siRNA chitosan nanoparticle can decrease the invasive capacity of gastric cancer cells in vitro.
PMID: 25345950 [PubMed - in process]
Source: Journal of Southern Medical University - October 1, 2014 Category: Universities & Medical Training Authors: Zhou XK, He L, Liang M, Liu JF Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of siRNA targeting HDAC1 gene on proliferation, apoptosis, histone acetylation, and histone metylation in gastric cancer cells in vitro.
CONCLUSION: Silencing HDAC1 gene expression with HDAC1 siRNA can promote histone H3 and H4 acetylation and inhibit histone methylation of H3K9 to suppress the proliferation and induce apoptosis of gastric cancer MGC-803 cells.
PMID: 24589606 [PubMed - in process]
Source: Journal of Southern Medical University - February 20, 2014 Category: Universities & Medical Training Authors: Zhuang HX, Ma XD, Lai YD, Xu XN, Wang XZ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Comparison of efficiency and cytotoxicity of different transfection reagents in transfecting RIP140-siRNA into Kupffer cells.
CONCLUSION: In Kupffer cells, lentivirus-mediated transfection, as compared with the other two trasnfection reagents, can achieve good transfection efficiency with a relativelty low cytotoxicity, and allows for better controllability and stability of the trasnfectiion conditions.
PMID: 26714899 [PubMed - in process]
Source: Journal of Southern Medical University - December 20, 2015 Category: Universities & Medical Training Authors: Li J, Liu ZJ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
siRNA-mediated CDK6 knockdown suppresses nasopharyngeal carcinoma cell growth and cell cycle transition in vitro.
CONCLUSION: NPC tissues overexpress CDK6. Knocking down CDK6 expression inhibits the growth and cell cycle transition of NPC cells in vitro by inhibiting the expressions of CDK4, CCND1, and E2F1 and upregulating tumor suppressor p21 expression.
PMID: 25057088 [PubMed - in process]
Source: Journal of Southern Medical University - July 20, 2014 Category: Universities & Medical Training Authors: Luo XP, Xia Q, Qin JX, Huang YZ, Liu J, Wang Y, Wang HF, Chen JJ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
EZH2 gene silenced by siRNA suppresses the growth and invasion of endometrial carcinoma cells.
CONCLUSION: EZH2 expression is increased in endometrial carcinoma tissues. Knocking down EZH2 expression suppresses the cell growth, cell cycle transition and cell invasion by downregulated E2F1 and MMP9, and upregulated tumor suppressor p21 expression.
PMID: 23803199 [PubMed - in process]
Source: Journal of Southern Medical University - June 20, 2013 Category: Universities & Medical Training Authors: Leng LZ, Huang QT, Dong YN, Yu H, Tian Y, Peng GQ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Numb activates the mTORC1 signaling pathway in proximal tubular epithelial cells by upregulating V1G1 expression
CONCLUSION: Numb promotes the activation of mTORC1 signaling in proximal tubular epithelial cells by upregulating V1G1 expression.PMID:36329579 | DOI:10.12122/j.issn.1673-4254.2022.10.04
Source: Journal of Southern Medical University - November 4, 2022 Category: Universities & Medical Training Authors: Z Liu D You Y Li Y He A Li P Li C Li Source Type: research
