Filtered By:
Source: International Journal of Oncology

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 198 results found since Jan 2013.

Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
Abstract p53, one of the most frequently mutated genes in colon cancer, suppresses cancer development through transactivation of its targets. Herein, we conducted a comprehensive analysis of the p53 downstream pathway in colorectal cancer by using multi-omics analysis. Mass spectrometric analysis of HCT116 p53+/+ and HCT116 p53-/- cells treated with adriamycin identified 124 proteins increased by DNA damage in a p53-dependent manner. Further screening using a cDNA microarray and the TCGA database revealed MICALL1 as a novel p53 target, and we identified functional p53 binding motifs located approximately 3000 b...
Source: International Journal of Oncology - July 18, 2017 Category: Cancer & Oncology Authors: Takahashi Y, Tanikawa C, Miyamoto T, Hirata M, Wang G, Ueda K, Komatsu T, Matsuda K Tags: Int J Oncol Source Type: research

Epithelial-mesenchymal transition and cancer stem cell-like phenotype induced by Twist1 contribute to acquired resistance to irinotecan in colon cancer.
Abstract Inherent and acquired chemoresistance reduce the effectiveness of irinotecan in the treatment of metastatic colorectal cancer (CRC). However, the molecular mechanisms underlying this resistance process are still unclear. Twist1 is one of the master transcription factors of epithelial-mesenchymal transition (EMT). Our previous study indicated that Twist1 is overexpressed in colon cancer tissues, and demonstrated that Twist1 plays a crucial role in the chemoresistance of CRC. In the present study, we further investigated how Twist1 contribute to acquired resistance to irinotecan in colon cancer. The irinote...
Source: International Journal of Oncology - June 14, 2017 Category: Cancer & Oncology Authors: Yang Y, Wang G, Zhu D, Huang Y, Luo Y, Su P, Chen X, Wang Q Tags: Int J Oncol Source Type: research

CCL21/CCR7 interaction promotes cellular migration and invasion via modulation of the MEK/ERK1/2 signaling pathway and correlates with lymphatic metastatic spread and poor prognosis in urinary bladder cancer.
Abstract Lymph node metastasis in patients with urinary bladder cancer (UBC) is always associated with poor prognosis and is the determinant for tumor staging and the development of treatment regimens; however, its underlying mechanisms remain to be studied. Immunohistochemical staining of tumor sections from 62 UBC patients was performed using CCR7, D2-40 and CD34 antibodies. We showed that increased CCR7 expression was significantly associated with positive lymph node status (P=0.008), pT3-T4 tumor stage (P=0.015), tumor grade (P=0.010) and worse overall survival (OS, P<0.001) and that both CCR7 expression an...
Source: International Journal of Oncology - May 17, 2017 Category: Cancer & Oncology Authors: Xiong Y, Huang F, Li X, Chen Z, Feng D, Jiang H, Chen W, Zhang X Tags: Int J Oncol Source Type: research

Dual strands of pre-miR ‑150 (miR‑150‑5p and miR‑150‑3p) act as antitumor miRNAs targeting SPOCK1 in naïve and castration-resistant prostate cancer.
Dual strands of pre-miR‑150 (miR‑150‑5p and miR‑150‑3p) act as antitumor miRNAs targeting SPOCK1 in naïve and castration-resistant prostate cancer. Int J Oncol. 2017 May 17;: Authors: Okato A, Arai T, Kojima S, Koshizuka K, Osako Y, Idichi T, Kurozumi A, Goto Y, Kato M, Naya Y, Ichikawa T, Seki N Abstract Analysis of our microRNA (miRNA) expression signature in human cancers has shown that guide and passenger strands of pre-miR‑150, i.e., miR‑150‑5p and miR‑150‑3p, are significantly downregulated in cancer tissues. In miRNA biogenesis, the passenger strand of miRNA is degraded and...
Source: International Journal of Oncology - May 17, 2017 Category: Cancer & Oncology Authors: Okato A, Arai T, Kojima S, Koshizuka K, Osako Y, Idichi T, Kurozumi A, Goto Y, Kato M, Naya Y, Ichikawa T, Seki N Tags: Int J Oncol Source Type: research

The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma.
Abstract T-cell lymphoblastic lymphoma (T-LBL) is an aggressive malignancy with poor prognosis and high recurrence rate. Long non-coding RNA (lncRNA)-MEG3 is an important tumor suppressor in various cancers. The present study investigated the potential role of maternally expressed gene 3 (MEG3) in the progression of T-LBL. Suppressed expression of MEG3 was detected in T-LBL tissues compared with adjacent histologically normal tissues. Down-regulated level of MEG3 was also found in three T-LBL cell lines (CCRF-CEM, Jurkat and SUP-T1) compared with human T-cell line H9. The proliferation of T-LBL cells was inhibited...
Source: International Journal of Oncology - May 17, 2017 Category: Cancer & Oncology Authors: Fan FY, Deng R, Yi H, Sun HP, Zeng Y, He GC, Su Y Tags: Int J Oncol Source Type: research

Crizotinib, a MET inhibitor, prevents peritoneal dissemination in pancreatic cancer.
Abstract Peritoneal dissemination is a frequent occurrence in pancreatic cancer, which is associated with a poor prognosis. MET is associated with the progression of pancreatic cancer; therefore, we evaluated the effect of a MET inhibitor, crizotinib, on peritoneal dissemination of pancreatic cancer. Crizotinib inhibited the growth of 8 pancreatic cancer cell lines with the IC50 ranging from 1.4 to 4.3 µM. Invasion of the pancreatic cancer cell line Suit-2, was suppressed in vitro at a concentration of 1.0 µM, which is sufficient for the inhibition of MET phosphorylation. This effect on cell invasion was also...
Source: International Journal of Oncology - May 11, 2017 Category: Cancer & Oncology Authors: Takiguchi S, Inoue K, Matsusue K, Furukawa M, Teramoto N, Iguchi H Tags: Int J Oncol Source Type: research

Emmprin, released as a microvesicle in epithelioid sarcoma, interacts with fibroblasts.
In this study, we used microvesicles derived from sarcoma cells, and determined whether emmprin exists in the microvesicles, which enhance the production of MMP-2 via fibroblasts. Microvesicles released from FU-EPS-1 cells were shown to contain full-length emmprin, identified as a 45-kDa protein characterized by polylactosamine glycosylation. Microvesicles collected from FU-EPS-1 cells transfected with emmprin-specific siRNA or transduced with shRNA displayed significantly reduced MMP-2 production by fibroblasts compared with those from control-transfected cells. Our findings show that emmprin is released through microvesi...
Source: International Journal of Oncology - May 8, 2017 Category: Cancer & Oncology Authors: Aoki M, Koga K, Hamasaki M, Egawa N, Nabeshima K Tags: Int J Oncol Source Type: research

Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.
In conclusion, we suggest that GAS contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1. PMID: 28498440 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - May 4, 2017 Category: Cancer & Oncology Authors: Zhuang K, Zhang L, Zhang X, Tang H, Zhang J, Yan Y, Han K, Guo H Tags: Int J Oncol Source Type: research

Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition.
Abstract The significance of indoleamine 2,3-dioxygenase-1 (IDO1) has been studied in various types of tumors, but the relationship between IDO1 and tumor angiogenesis needs further delineation. We aimed to clarify the relationship between tumor angiogenesis and IDO1 expression, and to explore the possibility of IDO1-targeting molecular therapy for lung cancer. For the first time, we found that silencing the IDO1 gene using small interfering RNA (siRNA) inhibits in vitro cancer cell invasion and migration. We further demonstrated that knockdown of IDO1 decreased the formation of vasculogenic mimicry. In addition ...
Source: International Journal of Oncology - April 25, 2017 Category: Cancer & Oncology Authors: Pan J, Yuan K, Peng S, Huang Y, Zhang Y, Hu Y, Feng Y, Shi Y, Liu Y, Wang H, Zhou N, Min W Tags: Int J Oncol Source Type: research

Smad4 deletion in blood vessel endothelial cells promotes ovarian cancer metastasis.
Abstract SMAD4 is a critical co-smad in signal transduction pathways activated in response to transforming growth factor-β (TGF-β)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4 inactivation in tumors highlighted it as a tumor-suppressor gene. Herein, we report that loss of SMAD4 expression in vascular endothelial cells promotes ovarian cancer invasion. SiRNA transfer of this gene in the HUVEC reduced SMAD4 protein expression and function. Although it reduced the vessel endothelial cell tubule formation in vitro and in vivo, it did not affect the tumor growth significantl...
Source: International Journal of Oncology - April 7, 2017 Category: Cancer & Oncology Authors: Yang J, Wang Y, Zeng Z, Qiao L, Zhuang L, Gao Q, Ma D, Huang X Tags: Int J Oncol Source Type: research

Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor  2 through FAK/PI3K/Rac1/mdm2 signaling.
Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling. Int J Oncol. 2017 Apr 03;: Authors: Gao F, Wang FG, Liu RR, Xue F, Zhang J, Xu GQ, Bi JH, Meng Z, Huo R Abstract Hemangiomas are the most common vascular tumors that occur frequently in prematures and females. microRNA (miR)-130a is associated with the growth and invasion in many tumors, and its role in hemangiomas has not been addressed so far. The present study revealed that miR‑130a was overexpressed in infantile hemangioma tissues compared with matched tum...
Source: International Journal of Oncology - April 3, 2017 Category: Cancer & Oncology Authors: Gao F, Wang FG, Liu RR, Xue F, Zhang J, Xu GQ, Bi JH, Meng Z, Huo R Tags: Int J Oncol Source Type: research

Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Abstract The epithelial-to-mesenchymal transition (EMT) is an initial, critical step in hepatocellular carcinoma (HCC) tumor invasion and metastasis. Frizzled 2 (Fzd2) expression might drive EMT through the non-canonical Wnt pathway, one of the various EMT signaling pathways. The expression of epithelial (E-cadherin) and mesenchymal (vimentin) markers, as well as that of Wnt5b, Stat3, IL-6, Jak2 and Fzd2, were measured in 15 HCC cell lines. The EMT status (vimentin to E-cadherin mRNA expression ratio), Fzd2 mRNA expression, and pSTAT3 protein expression were assessed by immunostaining in 100 HCC patients, and ...
Source: International Journal of Oncology - March 27, 2017 Category: Cancer & Oncology Authors: Asano T, Yamada S, Fuchs BC, Takami H, Hayashi M, Sugimoto H, Fujii T, Tanabe KK, Kodera Y Tags: Int J Oncol Source Type: research

SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway.
Abstract Prostate cancer is the second leading cause of cancer deaths among men in Western counties and has increased in incidence also in China in recent years. Although diagnosis modalities for primary prostate cancer have markedly improved, there are still no effective therapies for metastatic prostate cancer. SU6668 is an inhibitor of the tyrosine kinase activity of three angiogenic receptors VEGFR2, PDGFRβ and FGFR1. There is strong experimental evidence that SU6668 can induce growth inhibition of various primary tumors. However, the function and molecular mechanism of SU6668 in prostate cancer has not been ...
Source: International Journal of Oncology - March 22, 2017 Category: Cancer & Oncology Authors: Qian B, Yao Y, Liu C, Zhang J, Chen H, Li H Tags: Int J Oncol Source Type: research

p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage.
This study was aimed at uncovering potential mechanisms of p53 regarding microRNA-374b and v-akt murine thymoma viral oncogene homolog 1 (AKT1) during DNA damage of CRC cells. CRC cells HCT116 and HT29 were transfected with p53-specific small interfering RNA (siRNA), p53 overexpression vector or miR-374b inhibitor, and then treated with 10 µM bleomycin (BLM) for 24 h to induce DNA damage. Primary (pri), precursor (pre) and mature miR-374b levels were quantified by qRT-PCR. AKT1 and p53 protein levels were detected by western blotting. Cell apoptosis changes were assessed by flow cytometry. AKT1 mRNA was detected to be ...
Source: International Journal of Oncology - March 21, 2017 Category: Cancer & Oncology Authors: Gong H, Cao Y, Han G, Zhang Y, You Q, Wang Y, Pan Y Tags: Int J Oncol Source Type: research

Silencing Snail suppresses tumor cell proliferation and invasion by reversing epithelial-to-mesenchymal transition and arresting G2/M phase in non-small cell lung cancer.
Abstract Epithelial-to-mesenchymal transition (EMT) is essential for tumor invasion and metastasis. Snail has been proven to be a key regulator of EMT. Several studies have shown compelling evidence that Snail is also an important regulator of tumor growth and aggression; however, the role of Snail in the cell cycle has not been clarified. We decreased Snail expression by siRNA transfection and lentiviral‑mediated RNAi, to explore the effect of silencing Snail on the tumorigenicity and migration of lung carcinoma (lung cancer) cells. The results showed that silencing Snail conferred significant anti-proliferativ...
Source: International Journal of Oncology - February 20, 2017 Category: Cancer & Oncology Authors: Yang X, Han M, Han H, Wang B, Li S, Zhang Z, Zhao W Tags: Int J Oncol Source Type: research