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Long Non-Coding RNA PVT1 Facilitates Cervical Cancer Progression Via Negative Regulating of miR-424.
Authors: Gao YL, Zhao ZS, Zhang MY, Han LJ, Dong YJ, Xu B Abstract Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue. Bioinformatics analysis re...
Source: Oncology Research - March 10, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Gamma Irradiation Upregulates B-cell Translocation Gene 2 to Attenuate Cell Proliferation of Lung Cancer Cells Through JNK and NF κB Pathways.
In this study, we aimed to explore the role of γ-ray treatment and correlation with BTG2 in cell proliferation, apoptosis and cell cycle arrest regulation in lung cancer cell line. A549 cell viability, apoptosis rate, and cell cycle were investigated after γ-ray treatment. Then we used siRNA for BTG2 to detect the effect of BTG2 knockdown on the progress of γ-ray treated lung cancer cell. Finally, we investigated the singling pathway that γ-ray might regulate BTG2. We found that γ-ray inhibited A549 cell viability, promoted apoptosis and cell cycle arrest. While the BTG2 knockdown could relieve the effect caused by γ...
Source: Oncology Research - March 3, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research