Filtered By:
Source: Toxicology Letters

This page shows you your search results in order of date. This is page number 2.

Order by Relevance | Date

Total 86 results found since Jan 2013.

Methamphetamine mediates apoptosis of vascular smooth muscle cells via the Chop-related endoplasmic reticulum stress pathway
We examined the expression of the apoptosis-related proteins Caspase 3 and PARP after METH treatment in vivo and in vitro and detected the expression of endoplasmic reticulum stress-related proteins. After treatment with the endoplasmic reticulum stress inhibitor 4-PBA, changes in the above indicators were examined. C/EBP homologous protein (Chop) expression was also detected, and the relationship between endoplasmic reticulum stress and apoptosis was further determined by siRNA silencing of Chop. The results indicated that METH can induce apoptosis of vascular smooth muscle cells (VSMCs) and upregulate the expression of C...
Source: Toxicology Letters - July 2, 2021 Category: Toxicology Authors: Xiaohui Tan Dunpeng Cai Na Chen Sihao Du Dongfang Qiao Xia Yue Tao Wang Jia Li Weibing Xie Huijun Wang Source Type: research

PPAR γ mediates the anti-pulmonary fibrosis effect of icaritin
CONCLUSIONS: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.PMID:34153405 | DOI:10.1016/j.toxlet.2021.06.014
Source: Toxicology Letters - June 21, 2021 Category: Toxicology Authors: Qingzhong Hua Xiaoting Huang Weixi Xie Feiyan Zhao Haipeng Cheng Ziqiang Luo Jianzhong Han Zun Wang Qian Zeng Miao Lin Tingting Zhou Jialu Zhang Can Gu Wei Liu Siyuan Tang Source Type: research

TNF α enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy
Toxicol Lett. 2021 Feb 17:S0378-4274(21)00049-7. doi: 10.1016/j.toxlet.2021.02.009. Online ahead of print.ABSTRACTTrovafloxacin (TVX) is associated with idiosyncratic drug-induced liver injury (iDILI) and inflammation-mediated hepatotoxicity. However, the inflammatory stress-regulated mechanisms in iDILI remain unclear. Herein, we elucidated the novel role of tumor-necrosis factor alpha (TNFα), an inflammatory stress factor, in TVX-induced in vitro hepatotoxicity and synergistic toxicity. TVX specifically induced synergistic toxicity in HepG2 cells with TNFα, which inhibits autophagy. TVX-treated HepG2 cells induced prot...
Source: Toxicology Letters - February 20, 2021 Category: Toxicology Authors: Jun-Ho Ahn Hyun Jegal Mi-Sun Choi Soojin Kim Se-Myo Park Jaehwan Ahn Hyoung-Yun Han Hyun-Soo Cho Seokjoo Yoon Jung-Hwa Oh Source Type: research

TNF α enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy.
TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 Feb 17;: Authors: Ahn JH, Jegal H, Choi MS, Kim S, Park SM, Ahn J, Han HY, Cho HS, Yoon S, Oh JH Abstract Trovafloxacin (TVX) is associated with idiosyncratic drug-induced liver injury (iDILI) and inflammation-mediated hepatotoxicity. However, the inflammatory stress-regulated mechanisms in iDILI remain unclear. Herein, we elucidated the novel role of tumor-necrosis factor alpha (TNFα), an inflammatory stress factor, in TVX-induced in vitro hepatotoxicity and synergistic toxicity. TVX s...
Source: Toxicology Letters - February 17, 2021 Category: Toxicology Authors: Ahn JH, Jegal H, Choi MS, Kim S, Park SM, Ahn J, Han HY, Cho HS, Yoon S, Oh JH Tags: Toxicol Lett Source Type: research

Regulation of CRMP2 by Cdk5 and GSK-3 β Participates in Sevoflurane-induced Dendritic Development Abnormalities and Cognitive Dysfunction in Developing Rats.
CONCLUSION: Cdk5/CRMP2 and GSK-3β/CRMP2 pathways participate in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats. PMID: 33548343 [PubMed - as supplied by publisher]
Source: Toxicology Letters - February 3, 2021 Category: Toxicology Authors: Liao Z, Huang Z, Li J, Li H, Miao L, Liu Y, Zhang J, Xu Y, Li Y Tags: Toxicol Lett Source Type: research

Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.
Abstract Chromium (Cr) (VI) is a proven toxin, mutagen and carcinogen. Here, the role of high mobility group A2 (HMGA2) mediating Cr (VI)-induced mitophagy was investigated. Cr (VI)-treatment caused the formation of double membrane autophagic vesicles (AVs) engulfing mitochondria and increased the expression of PINK1, PARK2, LC3 as well as HMGA2 particularly in mitochondria in A549 cells. Silencing of HMGA2 by siRNA decreased expression of PINK1, PARK2 and LC3 II especially in mitochondria, while over-expression of HMGA2 increased the expression of them in A549 cells. It indicated that HMGA2 played a critical role...
Source: Toxicology Letters - August 27, 2020 Category: Toxicology Authors: Gao Z, Mei J, Yan X, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J Tags: Toxicol Lett Source Type: research

Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: a transcriptomic study.
In conclusion, the results of this study revealed the induction of LDs by MWCNTs in a diameter-dependent manner through the activation of PPAR signalling pathway. PMID: 32649966 [PubMed - as supplied by publisher]
Source: Toxicology Letters - July 6, 2020 Category: Toxicology Authors: Yang T, Chen J, Gao L, Huang Y, Liao G, Yi C Tags: Toxicol Lett Source Type: research