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Source: Toxicology Letters
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Total 70 results found since Jan 2013.
Epigenetic reader MeCP2 repressed WIF1 boosts lung fibroblast proliferation, migration and pulmonary fibrosis
Toxicol Lett. 2023 Apr 13:S0378-4274(23)00164-9. doi: 10.1016/j.toxlet.2023.04.004. Online ahead of print.ABSTRACTEpigenetic has been implicated in pulmonary fibrosis. However, there is limited information regarding the biological role of the epigenetic reader MeCP2 in pulmonary fibrosis. The aim of this study was to investigate the role of MeCP2 and its target WIF1 in pulmonary fibrosis. The pathological changes and collagen depositions was analyzed by H&E, Masson's Trichrome Staining and Sirius Red staining. MeCP2, WIF1, α-SMA, Wnt1, β-catenin, and collagen I expression were analyzed by western blotting, RT-qPCR, i...
Source: Toxicology Letters - April 15, 2023 Category: Toxicology Authors: Ji-Ming Sha Ren-Quan Zhang Xian-Chen Wang Yang Zhou Kai Song He Sun Bin Tu Hui Tao Source Type: research
The Lnc-HOTAIR/miR122/PPAR γ signaling mediated the occurrence and continuous development of alcohol-induced Osteonecrosis of the femoral head
This study aimed to explore the mechanism of alcohol-induced Osteonecrosis of the femoral head (ONFH) through in vivo and in vitro experiments. In vitro, the Oil Red O staining showed that ethanol promoted extracellular adipogenesis in a dose-dependent manner. ALP staining and alizarin red staining showed that ethanol inhibited the formation of extracellular mineralization in a dose-dependent manner. The Oil Red O staining showed that miR122 mimics and Lnc-HOTAIR SiRNA rescued extracellular adipogenesis induced by ethanol in BMSCs. Besides, we found that the high expression of PPARγ in BMSCs recruited histone deacetylase ...
Source: Toxicology Letters - April 6, 2023 Category: Toxicology Authors: Hanwen Luo Guoping Le Mengting Lu Li Li Source Type: research
Tyrphostin AG1024 downregulates aryl hydrocarbon receptor (AhR) expression in an IGF1R and IR-independent manner
In this study, we screened for important molecules for AhR activation using SCAD inhibitor kits. Among 164 kinase inhibitors listed in these kits, tyrphostin AG1024, commonly used as an inhibitor of insulin-like growth factor receptor (IGF1R) and insulin receptor (IR), was identified as a potent inhibitor of 3-methylcholanthrene (MC)-mediated AhR activation. We further investigated the mechanism by which AG1024 suppresses MC-mediated AhR activation. AG1024 decreased AhR-dependent luciferase activity, CYP1A1 gene expression, and its protein expression. However, when IGF1R siRNA and IR siRNA were used, AhR activation was sli...
Source: Toxicology Letters - February 12, 2022 Category: Toxicology Authors: Shunsuke Tomita Kazuho Inaba Masashi Sekimoto Source Type: research
Role of scavenger receptors in silica nanoparticle-induced cytokine responses in bronchial epithelial cells
In conclusion, LOX-1 and CXCL16 and especially SR-B1 seem to have important roles in mediating cytokine responses and TGF-α release due to SiNP exposure in BEAS-2B cells, without a down-stream role of MAP-kinase and NF-κB.PMID:34653535 | DOI:10.1016/j.toxlet.2021.10.004
Source: Toxicology Letters - October 15, 2021 Category: Toxicology Authors: Magne Refsnes Tonje Skuland Johan Øvrevik Marit L åg Source Type: research
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the Chop-related endoplasmic reticulum stress pathway
We examined the expression of the apoptosis-related proteins Caspase 3 and PARP after METH treatment in vivo and in vitro and detected the expression of endoplasmic reticulum stress-related proteins. After treatment with the endoplasmic reticulum stress inhibitor 4-PBA, changes in the above indicators were examined. C/EBP homologous protein (Chop) expression was also detected, and the relationship between endoplasmic reticulum stress and apoptosis was further determined by siRNA silencing of Chop. The results indicated that METH can induce apoptosis of vascular smooth muscle cells (VSMCs) and upregulate the expression of C...
Source: Toxicology Letters - July 2, 2021 Category: Toxicology Authors: Xiaohui Tan Dunpeng Cai Na Chen Sihao Du Dongfang Qiao Xia Yue Tao Wang Jia Li Weibing Xie Huijun Wang Source Type: research
