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Involvement of CTR1 and ATP7A in Lead (Pb)-induced Copper (Cu) Accumulation in Choroidal Epithelial Cells.
This study investigated the roles of Cu transporter 1 (CTR1) and ATP7A, two Cu transporters, in Pb-induced Cu accumulation in the choroidal epithelial cells. Pb exposure resulted in increased intracellular (64)Cu retention, accompanying with up-regulated CTR1 level. Knockdown of CTR1 using siRNA before Pb exposure diminished the Pb-induced increase of (64)Cu uptake. The expression level of ATP7A was down-regulated following the Pb exposure. ATP7A siRNA knockdown, or PCMB treatment, inhibited the (64)Cu efflux from the cells, while the following additional incubation with Pb failed to further increase the intracellular (64)...
Source: Toxicology Letters - December 5, 2013 Category: Toxicology Authors: Zheng G, Zhang J, Xu Y, Shen X, Song H, Jing J, Luo W, Zheng W, Chen J Tags: Toxicol Lett Source Type: research