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Source: Toxicology Letters
Condition: Diabetes
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Total 1 results found since Jan 2013.
ULK1-Regulated Autophagy: A Mechanism in Cellular Protection for ALDH2 against Hyperglycemia.
This study was designed to examine the mechanism behind ALDH2-offered protection against high glucose exposure with a focus on autophagy. H9C2 cells were cultured with normal or high glucose medium in the presence or absence of the ALDH2 agonist Alda-1. GFP-LC3 puncta and immunofluorescence were employed to assess autophagosome formation. Western blotting was applied to evaluate autophagy protein markers Atg5, LC3, p62, ULK1 phosphorylation and ALDH2. JC-1 staining was used to monitor mitochondrial membrane potential and mitochondrial injury. CCK-8 and TUNEL assays were employed for apoptosis and cell viability. Our result...
Source: Toxicology Letters - November 8, 2017 Category: Toxicology Authors: Liu M, Lu S, He W, Zhang L, Ma Y, Lv P, Ma M, Yu W, Wang J, Zhang M, Zhang Y, Li Y Tags: Toxicol Lett Source Type: research
