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Involvement of C/EBP β-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis.
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicol Lett. 2019 May 03;: Authors: Huang E, Huang H, Guan T, Liu C, Qu D, Xu Y, Yang J, Yan L, Xiong Y, Liang T, Wang Q, Chen L Abstract Methamphetamine (METH) is a widely abused illicit psychoactive drug. Our previous study has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in METH-induced neuronal autophagy and apoptosis. However, the detailed molecular mechanisms underlying this process remain poorly understood. Previous studies have demonstrated that DNA...
Source: Toxicology Letters - May 2, 2019 Category: Toxicology Authors: Huang E, Huang H, Guan T, Liu C, Qu D, Xu Y, Yang J, Yan L, Xiong Y, Liang T, Wang Q, Chen L Tags: Toxicol Lett Source Type: research

CDK5-mediated Tau Accumulation Triggers Methamphetamine-induced Neuronal Apoptosis via Endoplasmic Reticulum-Associated Degradation Pathway.
Abstract Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types, particularly neuronal cells. However, the underlying mechanisms of METH-induced neuronal apoptosis remain to be elucidated. Accumulation of microtubule-associated protein Tau can lead to activation of multiple neurotoxic pathways, which is closely correlated with neuronal apoptosis. The aim of this study was to determine the role of Tau in METH-induced neuronal apoptosis. We determined the expression of two phosphorylated Tau proteins (serine 396 and threonine 231) in the human neuroblastoma SH-SY5Y cells and in the hippoca...
Source: Toxicology Letters - April 26, 2018 Category: Toxicology Authors: Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H, Xie WB Tags: Toxicol Lett Source Type: research