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H1R mediates local anesthetic-induced vascular permeability in angioedema.
This study supported a key role of H1R in LA-induced angioedema, and suggested that in the design of LA structure, the ring formation of the N-methyl scaffold on the side chain can properly avoid the angioedema. PMID: 32061592 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - February 11, 2020 Category: Toxicology Authors: Cao J, Zhang Y, Che D, Liu R, Yang L, Zhang T, He L Tags: Toxicol Appl Pharmacol Source Type: research