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Cyclic Biaxial Tensile Strain Promotes Bone Marrow-Derived Mesenchymal Stem Cells to Differentiate into Cardiomyocyte-like Cells by miRNA-27a.
Abstract A physical stimuli, it has been reported that cyclic tensile strain can promote bone marrow-derived mesenchymal stem cells (BMSCs) to differentiate into cardiomyocytes, but the underlying mechanisms have been poorly elucidated so far. Here, we used a mimicking loading strain, cyclic biaxial tensile strain (CBTS), and found it can promote BMSCs to differentiate into cardiomyocytes. When the CBTS were loaded, the cells expressed cardiac-specific markers GATA4, TNNT2, MEF-2c, and Cx43, meanwhile we found miR-27a decreased and stem cell factor (SCF) increased. When we overexpressed miR-27a, the cardiac-specif...
Source: The International Journal of Biochemistry and Cell Biology - April 5, 2018 Category: Biochemistry Authors: Cao C, Li L, Li H, He X, Geng W, Xiaoqin Y Tags: Int J Biochem Cell Biol Source Type: research

The self-renewal of mouse embryonic stem cells is regulated by cell-substratum adhesion and cell spreading.
Abstract Mouse embryonic stem cells (mESCs) undergo self-renewal in the presence of the cytokine, leukaemia inhibitory factor (LIF). Following LIF withdrawal, mESCs differentiate, and this is accompanied by an increase in cell-substratum adhesion and cell spreading. The purpose of this study was to investigate the relationship between cell spreading and mESC differentiation. Using E14 and R1 mESC lines, we have restricted cell spreading in the absence of LIF by either culturing mESCs on chemically defined, weakly adhesive biomaterial substrates, or by manipulating the cytoskeleton. We demonstrate that by restricti...
Source: The International Journal of Biochemistry and Cell Biology - July 17, 2013 Category: Biochemistry Authors: Murray P, Prewitz M, Hopp I, Wells N, Zhang H, Cooper A, Parry KL, Short R, Antoine DJ, Edgar D Tags: Int J Biochem Cell Biol Source Type: research

Retinoic acid receptor beta mediates all-trans retinoic acid facilitation of mesenchymal stem cells neuronal differentiation.
Abstract All-trans retinoic acid plays an important role in nervous system development. However, the effects of all-trans retinoic acid on the neuronal differentiation of mesenchymal stem cells and the mechanisms through which this differentiation takes place are still poorly understood. Here, we investigated the biological effects of all-trans retinoic acid on the neuronal differentiation of mesenchymal stem cells and the signaling pathways that mediated these effects. We found that the neuronal differentiation efficiency of mesenchymal stem cells following all-trans retinoic acid pre-induction was greater and th...
Source: The International Journal of Biochemistry and Cell Biology - January 11, 2013 Category: Biochemistry Authors: Gong M, Bi Y, Jiang W, Zhang Y, Chen L, Hou N, Chen J, Li T Tags: Int J Biochem Cell Biol Source Type: research