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Leishmania donovani activates uncoupling protein 2 transcription to suppress mitochondrial oxidative burst through differential modulation of SREBP2, Sp1 and USF1 transcription factors.
Abstract In order to reside and multiply successfully within the host macrophages, Leishmania parasites impair the generation of cellular as well as mitochondrial reactive oxygen species (ROS), which is a major host defense mechanism against any invading pathogen. Mitochondrial uncoupling protein 2 (UCP2) is strongly induced in Leishmania infection, both at mRNA and protein levels, to suppress the mitochondrial ROS generation. In the present study we have demonstrated that L. donovani infection is associated with strong up-regulation of UCP2 at mRNA level which is the determining factor for its protein level upreg...
Source: The International Journal of Biochemistry and Cell Biology - January 10, 2014 Category: Biochemistry Authors: Ball WB, Mukherjee M, Srivastav S, Das PK Tags: Int J Biochem Cell Biol Source Type: research