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Source: The International Journal of Biochemistry and Cell Biology
Infectious Disease: Hepatitis B
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Total 1 results found since Jan 2013.
XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B.
Abstract
As an endoplasmic reticulum (ER) stress-related protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) is involved in inflammatory diseases, such as rheumatoid arthritis. However, the mechanisms of the transcriptional regulation of MANF is still undefined. Here, we showed that MANF expression was upregulated in hepatitis B tissues and hepatoma cells, and positively correlated with the spliced X-box binding protein-1 (XBP1s). Both overexpression of XBP1s and tunicamycin treatment were able to enhance MANF transcription. On the contrary, inhibition of XBP1 splicing by IRE1α endonuclease inhibi...
Source: The International Journal of Biochemistry and Cell Biology - April 9, 2018 Category: Biochemistry Authors: Wang D, Hou C, Cao Y, Cheng Q, Zhang L, Li H, Feng L, Shen Y Tags: Int J Biochem Cell Biol Source Type: research
