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Source: Developmental and Comparative Immunology
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Total 60 results found since Jan 2013.
Bombyx mori Tetraspanin A (BmTsp.A) is a facilitator in BmNPV invasion by regulating apoptosis
This study focused on the sequence features, analysis of expression pattern, as well as the effect of BmTsp.A on BmNPV (Bombyx mori nucleopolyhedrovirus) infection in the apoptotic pathway. BmTsp.A features the typical tetraspanins family, including four transmembrane domains and a major large extracellular loop domain. It is highly expressed specifically in the malpighian tubes, and its expression is increased by BmNPV induction for 48 h and 72 h. Overexpression and RNAi (RNA interference) mediated by siRNA reveal that BmTsp.A can promote the infection and replication of the virus. In addition, the overexpression of BmTsp...
Source: Developmental and Comparative Immunology - May 19, 2023 Category: Allergy & Immunology Authors: Xianghan Mei Peitong Qiao Hengheng Ma Siyu Qin Xia Song Qiaoling Zhao Dongxu Shen Source Type: research
Toll-interacting protein negatively regulated innate immune response via NF- κB signal pathway in blunt snout bream, Megalobrama amblycephala
Dev Comp Immunol. 2022 Nov 22:104595. doi: 10.1016/j.dci.2022.104595. Online ahead of print.ABSTRACTToll-interacting protein (Tollip) is an important negative regulator of Toll-like receptor-mediated innate immunity by preventing excessive proinflammatory responses. The structure and function of Tollip have been well identified in mammals, but the piscine Tollip remains poorly understood. In the present study, a homologue of Tollip was identified and characterized from blunt snout bream (named MaTollip), which was composed of an 831 bp open reading frame encoding a protein of 276 amino acids. Phylogenetic analysis indicate...
Source: Developmental and Comparative Immunology - November 25, 2022 Category: Allergy & Immunology Authors: Wenjun Wang Yang Liu Ying Mao Yandong Xu Zuzhen Wang Ru Zhang Bing Liu Kuanyu Xia Moci Yang Jinpeng Yan Source Type: research
Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF- α secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells
Dev Comp Immunol. 2022 Sep 29:104555. doi: 10.1016/j.dci.2022.104555. Online ahead of print.ABSTRACTClonorchis sinensis is closely associated with cholangitis, cholecystitis, biliary fibrosis and cholangiocarcinoma. The present study elucidated the role of extracellular vesicles of C. sinensis (CsEVs) in activating Toll-like receptor 9 (TLR9) and regulating inflammatory responses. The results showed that TLR9 expression was increased in the livers of C. sinensis-infected mice. CsEVs were cup-shaped or saucer-shaped and 80-120 nm in diameter. CsEVs activated TLR9 and promoted IL-6 and TNF-α expression in mouse biliary epit...
Source: Developmental and Comparative Immunology - October 2, 2022 Category: Allergy & Immunology Authors: Yuru Wang Xiaocen Wang Nan Zhang Yanhui Yu Penglin Bao Yeting Ma Haoyang Zhang Xu Zhang Xichen Zhang Pengtao Gong Xin Li Jianhua Li Source Type: research
Characterization and functional analysis of chicken dsRNA binding protein hnRNPU
Dev Comp Immunol. 2022 Aug 28:104521. doi: 10.1016/j.dci.2022.104521. Online ahead of print.ABSTRACTIn mammals, heterogeneous ribonucleoprotein U (hnRNPU), also named as nuclear matrix protein-nuclear scaffold attachment factor (SAFA), was originally identified as a DNA/RNA interactor protein. It has been reported that human hnRNPU facilitates IFN-β generation after vesicular stomatitis virus (VSV) infection. Nevertheless, the role of chicken hnRNPU (chhnRNPU) in IFN-β regulation as well as in infectious bursal diseases virus (IBDV) replication is still unclear. Here, we found that chhnRNPU inhibits IFN-β production via...
Source: Developmental and Comparative Immunology - August 31, 2022 Category: Allergy & Immunology Authors: Xifeng Hu Xiangdong Wu Zhen Ding Zheng Chen Huansheng Wu Source Type: research
Molecular cloning, prokaryotic expression and the anti-inflammatory activity of porcine PRDX5
In this study, the full-length cDNA encoding porcine PRDX5 (pPRDX5) was cloned. Subsequently, using porcine alveolar macrophages (PAMs), the target cells of PRRSV infection in vivo, we found that the recombinant pPRDX5 protein inhibited inflammatory responses induced by tumor necrosis factor alpha (TNF-α) or porcine reproductive and respiratory syndrome virus (PRRSV), a virus causing severe interstitial pneumonia in pigs. By contrast, knockdown of endogenous pPRDX5 with specific siRNA enhanced inflammatory responses induced by TNF-α or PRRSV. We also demonstrated that the involvement of pPRDX5 in inflammation regulation ...
Source: Developmental and Comparative Immunology - August 19, 2022 Category: Allergy & Immunology Authors: Panpan Ma Yanrong Zhou Puxian Fang Wenting Ke Shaobo Xiao Liurong Fang Source Type: research
Identification and characterization of DEAD-box RNA helicase DDX3 in rainbow trout (Oncorhynchus mykiss) and its relationship with infectious hematopoietic necrosis virus infection
This study suggests that DDX3 has an important role in host defense against IHNV infection and these results may provide new insights into IHNV pathogenesis and antiviral drug research.PMID:35840014 | DOI:10.1016/j.dci.2022.104493
Source: Developmental and Comparative Immunology - July 15, 2022 Category: Allergy & Immunology Authors: Jing-Zhuang Zhao Li-Ming Xu Guang-Ming Ren Yi-Zhi Shao Tong-Yan Lu Source Type: research
