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High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1 α/SIRT1 signaling pathway.
The objective of the research was to investigate the function of endothelial progenitor cells (EPCs) in the conditions of high glucose and lipids, which has been widely used to mimic the metabolic disorder that occurs in type 2 diabetic mellitus, and further to verify the role of PGC-1α and SIRT1, cellular energy metabolism regulators, in the process of senescence of EPCs with these combined stimuli. Circulating EPCs were incubated in absence or presence of high glucose (25 mM), FFA (200 μM) or both. EPCs senescence was assessed by β-galactosidase staining, EPCs telomerase activity was measured by telomeric repeat ampli...
Source: Cell Biology International - August 7, 2017 Category: Cytology Authors: Song X, Yang B, Qiu F, Jia M, Fu G Tags: Cell Biol Int Source Type: research

AMPK activation by prolonged stimulation with interleukin-1 β contributes to the promotion of GLUT4 translocation in skeletal muscle cells.
AMPK activation by prolonged stimulation with interleukin-1β contributes to the promotion of GLUT4 translocation in skeletal muscle cells. Cell Biol Int. 2016 Aug 29; Authors: Takaguri A, Inoue S, Kubo T, Satoh K Abstract Impaired insulin signaling in skeletal muscle cells causes insulin resistance associated with the onset of type 2 diabetes. Although interleukin (IL)-1β has been considered to be implicated in the pathogenesis of type 2 diabetes, the action of prolonged stimulation with IL-1β on the insulin signaling pathway in skeletal muscle cells remains poorly understood. In the current study,...
Source: Cell Biology International - August 28, 2016 Category: Cytology Authors: Takaguri A, Inoue S, Kubo T, Satoh K Tags: Cell Biol Int Source Type: research