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Calycosin suppresses colorectal cancer progression by targeting ER β, upregulating PTEN, and inhibiting PI3K/Akt signal pathway
In this study, we analyzed the effect of calycosin on the viability and apoptosis of human CRC HCT116 and SW480 cells via MTT assay, flow cytometry assay, and caspase-3/7 activity assay. The protein expressions of estrogen receptor β (ERβ), PTEN, and PI3K/Akt signal pathways were determined by Western blot analysis. And then, the alterations of biological behavior in CRC cells transfected with ERβ siRNA were analyzed. Mouse xenograft models were further performed to detect the antitumor effect in vivo. The results show that calycosin reduces CRC cell viability, induces cell apoptosis, and suppresses xenograft tumor grow...
Source: Cell Biology International - July 17, 2022 Category: Cytology Authors: Lin Zhu Sha Liu Yi-Fan Liao Yan-Mei Sheng Ji-Chun He Zheng-Xue Cai Qiong Man Yi-Ying Wu Source Type: research

Hexavalent chromium induces centrosome amplification through ROS-ATF6-PLK4 pathway in colon cancer cells
In conclusion, our results suggest that hexavalent chromium induces CA via the ROS-ATF6-PLK4 pathway and provides molecular targets for inhibiting chromium-mediated CA, which may be useful for the assessment of CA in chromium-promoted tumorigenesis and cancer cell metastasis. This article is protected by copyright. All rights reserved.PMID:35293662 | DOI:10.1002/cbin.11791
Source: Cell Biology International - March 16, 2022 Category: Cytology Authors: Xue Kai Bian Jia Li Guo Si Xian Xu Ya Wen Han Shao Chin Lee Ji Zhong Zhao Source Type: research

SOX-17 is involved in invasion and apoptosis of colorectal cancer cells through regulating miR-302b-3p expression
This study was conducted to explore the regulatory effect of SOX-17 on the expression of miR-302b-3p, and the involvement of SOX-17 in the invasion and apoptosis of CRC cells. The expression of SOX-17 and miR-302a,b,c,d-3p in colorectal cancer and normal colon epithelial cell lines was measured by real-time PCR and/or Western blot. The regulatory effects of SOX-17 on miR-302b-3p gene in HT29 and LoVo cells were tested using ChiP assay. The biological activities of SOX-17 and miR-302b-3p were evaluated by invasion and apoptosis assay. Results showed that transfection of SOX-17 siRNA (siSOX-17) significantly increased, where...
Source: Cell Biology International - March 19, 2021 Category: Cytology Authors: Fan Hu Mei Li Li Mo You Xiao Xiaoyan Wang Biao Xie Source Type: research

MicroRNA-93-5p expression in tumor tissue and its tumor suppressor function via targeting programmed death ligand-1 in colorectal cancer.
This article is protected by copyright. All rights reserved. PMID: 32068322 [PubMed - as supplied by publisher]
Source: Cell Biology International - February 17, 2020 Category: Cytology Authors: Chen YL, Wang GX, Lin BA, Huang JS Tags: Cell Biol Int Source Type: research

Role of km23-1 in Ras/ERK regulationkm23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells.
This article is protected by copyright. All rights reserved. PMID: 31393067 [PubMed - as supplied by publisher]
Source: Cell Biology International - August 7, 2019 Category: Cytology Authors: Raza A, Pandey MS, Jin Q, Mulder KM Tags: Cell Biol Int Source Type: research

Gene expression profile analysis of dbpA knockdown in colorectal cancer cells.
CONCLUSION: dbpA knockdown in SW620 cells altered the expression of carcinogenesis-associated genes in CRC and the involvement of dbpA on CRC might through MAPK signaling pathway, which might provide valuable evidence to further investigate the correlation between dbpA expression and CRC development. PMID: 27569444 [PubMed - as supplied by publisher]
Source: Cell Biology International - August 28, 2016 Category: Cytology Authors: Liu R, Wang G, Liu C, Qiu J, Yan L, Li X, Wang X Tags: Cell Biol Int Source Type: research

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