• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Significance of Oct-4 transcription factor as a pivotal therapeutic target for CD44 < sup > + < /sup > /24 < sup > - < /sup > mammary tumor initiating cells:  Aiming at the root of the recurrence
In this study, we have attempted to identify previously unrecognized CSC survival factors that can be used as druggable targets for bCSCs apoptosis regulators isolated from the TNBC line, MDA MB 468. After a thorough literature review, Oct-4 was identified as the most promising marker for its unique abundance in cancer and absence in normal cells and the contribution of Oct-4 to the sustenance of cancer cells. We then validated a very high expression of Oct-4 in the MDA MB 468 bCSCs population using flow-cytometry. The loss of Oct-4 was carried out using small interfering RNA (siRNA)-mediated knockdown in the bCSCs, follow...
Source: Cell Biology International - December 27, 2022 Category: Cytology Authors: Utsav Sen Shanooja Shanavas Apoorva H Nagendra Muhammad Nihad Debajit Chaudhury Hari K Rachamalla Rajkumar Banerjee Sudheer Shenoy P Bipasha Bose Source Type: research

ANKHD1 contributes to the malignant phenotype of triple-negative breast cancer cells
Cell Biol Int. 2022 Jul 16. doi: 10.1002/cbin.11844. Online ahead of print.ABSTRACTAnkyrin repeat and KH domain-containing protein 1, ANKHD1, has been identified as a regulator of signaling pathways and cellular processes of relevance in carcinogenesis. However, the role of ANKHD1 in breast cancer remains unclear. The aim of the present study was to characterize the expression pattern and involvement of ANKHD1 in the malignant phenotype of breast cancer cell lines and to investigate the clinical relevance of ANKHD1 in a breast cancer context. Gene and protein expressions were assessed in the cell lines by quantitative reve...
Source: Cell Biology International - July 17, 2022 Category: Cytology Authors: Bruna O de Almeida Larissa C de Almeida Leticia V Costa-Lotufo Jo ão A Machado-Neto Source Type: research

Epithelial cell adhesion molecule promotes breast cancer resistance protein -mediated multidrug resistance in breast cancer by inducing partial epithelial-mesenchymal transition
This article is protected by copyright. All rights reserved.PMID:33760350 | DOI:10.1002/cbin.11598
Source: Cell Biology International - March 24, 2021 Category: Cytology Authors: Rui-Zan Shi Yi-Fan He Jie Wen Ya-Nan Niu Yu Gao Lin-Hong Liu Xuan-Ping Zhang Yan Wang Xiu-Li Zhang Hui-Feng Zhang Min Chen Xiao-Ling Hu Source Type: research

Derlin-1 exhibits oncogenic activities and indicates unfavorable prognosis in breast cancer.
This article is protected by copyright. All rights reserved. PMID: 31670413 [PubMed - as supplied by publisher]
Source: Cell Biology International - October 30, 2019 Category: Cytology Authors: Zeng J, Tian Q, Zeng Z, Cai J, Ye M, Liu Y, Liu A Tags: Cell Biol Int Source Type: research

GPR120 is not required for ω-3 PUFAs-induced cell growth inhibition and apoptosis in breast cancer cells.
Abstract Intake of ω-3 PUFAs reduces the frequency of breast cancer, and GPR120 receptor transduces ω-3 PUFAs signaling to increase insulin sensitivity in mice, but whether GPR120 mediates ω-3 PUFAs signaling to inhibit breast carcinogenesis is currently unknown. In the present study, we found that GPR120 is highly expressed in human breast cancerous tissues but not adjacent normal tissue. Knockdown of GPR120 by siRNA in breast cancer cells significantly reduced cell growth, and dramatically increased ω-3 FFA-induced cell growth inhibition and apoptosis. Thus, these observations indicated that GPR120 promotes ...
Source: Cell Biology International - October 5, 2017 Category: Cytology Authors: Zhu S, Jiang X, Jiang S, Lin G, Gong J, Chen W, He Z, Chen YQ Tags: Cell Biol Int Source Type: research