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The TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with the NF90 protein.
In conclusion, TMEM98 mRNA enhanced the proliferation and invasion of GC cells by interacting with the NF90 protein. This article is protected by copyright. All rights reserved. PMID: 32379372 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 6, 2020 Category: Cytology Authors: Ao X, Li X, Chen Y, Zang Z, Guo W, Liang J Tags: Cell Biol Int Source Type: research

FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.
In conclusion, we first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effects of S100A4 in the cells. PMID: 28675500 [PubMed - as supplied by publisher]
Source: Cell Biology International - July 4, 2017 Category: Cytology Authors: Guo J, Bian Y, Wang Y, Chen L, Yu A, Sun X Tags: Cell Biol Int Source Type: research

Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo.
In this study, we found that OA induced autophagic cell death in multiple human gastric cancer cell lines. Moreover, OA-induced autophagy was shown for the first time in human gastric cancer cells, evidenced by the formation of GFP-RFP-LC3 puncta and autophagosomes. OA suppressed phospho-mTOR through inhibition of the PI3K/AKT and ERK/p38 MAPK signalling pathways and through activation of the AMPK signalling pathway. Furthermore, we found that OA-induced cytotoxicity and autophagy could be blocked by the autophagy inhibitor 3-methyladenine or via siRNA targeting Beclin-1. Our in vivo research showed that OA delayed the for...
Source: Cell Biology International - April 13, 2016 Category: Cytology Authors: Nie H, Wang Y, Qin Y, Gong XG Tags: Cell Biol Int Source Type: research

Bcl-2 down-regulation by small interfering RNA induces Beclin1-dependent autophagy in human SGC-7901 cells.
Abstract While Bcl-2 protein is involved in the regulation of apoptosis, recent research showed that Beclin1, described as the essential autophagy effector and haploinsufficent tumour suppressor, was originally isolated as a Bcl-2 interacting protein. Beclin1 interacts with Bcl-2 through a BH3 domain; nevertheless, the function of the anti-apoptotic gene, Bcl-2, in autophagy is not well understood. We explored the role of Bcl-2 in autophagy in human SGC-7901 cells in which Bcl-2 is overexpressed. Knockdown of Bcl-2 by small interfering RNA in human SGC-7901 cells downregulated Bcl-2 protein levels ∼82% and induc...
Source: Cell Biology International - July 7, 2014 Category: Cytology Authors: Du Y, Ji X Tags: Cell Biol Int Source Type: research

Inhibition of mTOR signaling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation.
Abstract Deregulation of the mammalian target of rapamycin pathway (mTOR pathway) is associated with human cancer. The relationship between mTOR pathway and histone acetylation is still unclear in gastric cancer. Immunohistochemistry was used to examine the phosphorylation of mTOR and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) in gastric cancer (GC) tissues. MKN45 and SGC7901 cells were treated with the mTOR inhibitor rapamycin (RAPA) alone or in combination with the phosphatidylinositol 3-kinase inhibitor LY294002 and the histone deacetylase (HDAC) inhibitor trichostatin A (TSA). Small...
Source: Cell Biology International - September 13, 2013 Category: Cytology Authors: Sun DF, Zhang YJ, Tian XQ, Chen YX, Fang JY Tags: Cell Biol Int Source Type: research