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NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma
In this study, we detected the upregulated expression of NAP1L1 mRNA and protein levels by quantitative polymerase chain reaction and Western blot analysis in NPC cell lines. Results of the immunohistochemistry analysis of NPC tissue biopsies showed that upregulated NAP1L1 protein expression promoted NPC progression and negatively correlated with poor prognosis in NPC patients. Suppression of NAP1L1 expression by small interfering RNA (siRNA) or small hairpin RNA (shRNA) methods significantly decreased cell proliferation in vivo and in vitro. Mechanism analysis revealed that the regulation of cell growth was enriched by Ge...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 26, 2021 Category: Drugs & Pharmacology Authors: YaHui Liu XiaoNing Li YeWei Zhang Yao Tang WeiYi Fang Xiong Liu Zhen Liu Source Type: research

PCSK9 and cancer: Rethinking the link
Biomed Pharmacother. 2021 May 28;140:111758. doi: 10.1016/j.biopha.2021.111758. Online ahead of print.ABSTRACTBACKGROUND: Cancer is emerging as a major problem globally, as it accounts for the second cause of death despite medical advances. According to epidemiological and basic studies, cholesterol is involved in cancer progression and there are abnormalities in cholesterol metabolism of cancer cells including prostate, breast, and colorectal carcinomas. However, the importance of cholesterol in carcinogenesis and thereby the role of cholesterol homeostasis as a therapeutic target is still a debated area in cancer therapy...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 31, 2021 Category: Drugs & Pharmacology Authors: Khadijeh Mahboobnia Matteo Pirro Ettore Marini Francesco Grignani Evgeny E Bezsonov Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Abstract Exploring key genes associated with non-small cell lung carcinoma (NSCLC) may lead to targeted therapies for NSCLC patients. The protein kinase MAP4K3 has been established as an important modulator of cell growth and autophagy in mammals. Herein, we investigated the somatic mutations and the expression pattern of MAP4K3 detected in NSCLC patients based on the TCGA database. Abnormal MAP4K3 expression and its somatic mutations are associated with the carcinogenesis and thereby becoming an attractive therapeutic target. Baicalein, a natural product, was determined to be the first-reported MAP4K3 binding l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 6, 2020 Category: Drugs & Pharmacology Authors: Li J, Yan L, Luo J, Tong L, Gao Y, Feng W, Wang F, Cui W, Li S, Sun Z Tags: Biomed Pharmacother Source Type: research

Non-coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR-18b-5p/VMA21 axis.
Abstract Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non-cancerous sample. The luciferase reporter gene assay reveals the relationship between LOXL1-AS1 and miR-18b-5p, miR-18b-5p and its target gene, Vacuolar ATPase Assembly Factor VMA21 (VMA21). Transfection of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 9, 2020 Category: Drugs & Pharmacology Authors: Xue F, Xu YH, Shen CC, Qin ZL, Zhou HB Tags: Biomed Pharmacother Source Type: research

Antitumor effects of disulfiram/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel.
Abstract The enhancement of the anticancer activity by disulfiram (DSF) chelated with copper (DSF/Cu2+) has been investigated recently, while the underlying molecular mechanisms still need to be fully elucidated. Chloride channel-3 (ClC-3) is over-expressed in a variety of cancers and involves multiple tumor biological events. However, whether the over-expression of ClC-3 in tumor cells affects the sensitivity of anti-tumor drugs remains unclear. Here, we showed that the involvement of ClC-3 chloride channel in the selective cytotoxicity of DSF/Cu2+ in the poorly-differentiated nasopharyngeal carcinoma. The EC50 o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 9, 2019 Category: Drugs & Pharmacology Authors: Xu X, Xu J, Zhao C, Hou X, Li M, Wang L, Chen L, Chen Y, Zhu L, Yang H Tags: Biomed Pharmacother Source Type: research

Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
Abstract Hepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms in hepatocarcinogenesis. Mixed lineage kinase (MLK)-4 is a member of the MLK family of mitogen-activated protein kinase kinase kinases, and modulates different cellular responses. However, its role in the meditation of HCC progression remains unclear. In the study, we found that MLK4 was over-expressed in tumor samples of HCC patients. High MLK4 expression was significantly associated with shorter overall survival in HC...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 5, 2019 Category: Drugs & Pharmacology Authors: Li Y, Zuo H, Wang H, Hu A Tags: Biomed Pharmacother Source Type: research

Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/ β-catenin pathway.
Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway. Biomed Pharmacother. 2019 Apr 10;114:108825 Authors: Zhang L, Li S, Wang R, Chen C, Ma W, Cai H Abstract Large tumor suppressor 2 (LATS2), an important mediator of the cell apoptotic response pathway, has been linked to the progression of several cancers. Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro. Western blotting was used to detect the expression of LATS2 and its downstream factors. ELISA, immunofluorescence, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2019 Category: Drugs & Pharmacology Authors: Zhang L, Li S, Wang R, Chen C, Ma W, Cai H Tags: Biomed Pharmacother Source Type: research

Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling.
In conclusion, our results highlight the importance of CDKN3 in PC and provide new insights into diagnostics and therapeutics of the PC. PMID: 29196103 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 28, 2017 Category: Drugs & Pharmacology Authors: Yu C, Cao H, He X, Sun P, Feng Y, Chen L, Gong H Tags: Biomed Pharmacother Source Type: research

Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation.
Abstract Cancer-associated fibroblasts (CAFs) play important roles in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC). However, effect of CAFs on chemotherapy resistance of TSCC remains largely obscure. Here, we cultured the matched primary CAFs and normal fibroblasts (NFs) pairs and detected their roles in cisplatin sensitivity of TSCC, as well as autophagy-related protein LC3 and Beclin1 expressions. During exposure to cisplatin, TSCC with CAFs group exhibited significantly increased cell viability and IC50, but reduced apoptosis than that with NFs group. Meanwhile, cisplatin increased t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 14, 2017 Category: Drugs & Pharmacology Authors: Liao JK, Zhou B, Zhuang XM, Zhuang PL, Zhang DM, Chen WL Tags: Biomed Pharmacother Source Type: research

Physcion 8-O- β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.
This study is aimed to investigate the anti-tumor activity of physcion 8-O-β-glucopyranoside (PG) in HCC. Our results have showed that PG significantly suppresses cell growth and induces apoptosis in vitro and in vivo. At molecular level, PG represses the expression of Pim family kinases 1 (PIM1), which is responsible for the anti-tumor effect of PG in HCC. Ectopic over-expression of PIM1 significantly abrogates the suppressing effect of PG on cell growth and inducing effect of PG on apoptosis. In contrast, knockdown of PIM1 by siRNA enhances the anti-tumor effect of PG in HCC cells. PMID: 28570979 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2017 Category: Drugs & Pharmacology Authors: Wang Q, Jiang Y, Guo R, Lv R, Liu T, Wei H, Ming H, Tian X Tags: Biomed Pharmacother Source Type: research

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