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The performance and perspectives of dendritic cell vaccines modified by immune checkpoint inhibitors or stimulants
Biochim Biophys Acta Rev Cancer. 2022 Jul 21:188763. doi: 10.1016/j.bbcan.2022.188763. Online ahead of print.ABSTRACTTherapeutic dendritic cell (DC) vaccines stimulate the elimination of tumor cells by the immune system. However, while antigen-specific T cell responses induced by DC vaccines are commonly observed, the clinical response rate is relatively poor, necessitating vaccine optimization. There is evidence that the suppression of DC function by immune checkpoints hinders the anti-tumor immune responses mediated by DC vaccines, ultimately leading to the immune escape of the tumor cells. The use of immune checkpoint i...
Source: Biochimica et Biophysica Acta - July 25, 2022 Category: Biochemistry Authors: Jiage Ding Yanyan Zheng Gang Wang Junnian Zheng Dafei Chai Source Type: research

Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 20:166326. doi: 10.1016/j.bbadis.2021.166326. Online ahead of print.ABSTRACTNormal cells depend on autophagy to maintain cellular homeostasis by recycling damaged organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis, targeting autophagy has been under attention in cancer therapy. However, autophagy has both pro-survival and pro-death functions in tumors, and its targeting requires further elucidation. The current review focuses on using nanoparticles for targeting autophagy in cancer treatment. Nanocarriers can deliver autophagy regulators along wit...
Source: Biochimica et Biophysica Acta - December 23, 2021 Category: Biochemistry Authors: Mahshid Deldar Abad Paskeh Maliheh Entezari Courtney Clark Amirhossein Zabolian Ehsan Ranjbar Mahdi Vasheghani Farahani Hossein Saleki Seyed Omid Sharifzadeh Fatemeh Bakhtiari Far Milad Ashrafizadeh Saeed Samarghandian Haroon Khan Saeid Ghavami Ali Zarrab Source Type: research

Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.
Abstract Chemotherapy resistance is a major problem in the treatment of cancer, but the underlying mechanisms are not fully understood. We found that the expression levels of claudin-1 (CLDN1) and 3, tight junctional proteins, are upregulated in cisplatin (CDDP)-resistant human lung adenocarcinoma A549 (A549R) cells. A549R cells showed cross-resistance to doxorubicin (DXR). Here, the expression mechanism and function of CLDN1 and 3 were examined. CLDN1 and 3 were mainly localized at tight junctions concomitant with zonula occludens (ZO)-1, a scaffolding protein, in A549 and A549R cells. The phosphorylation levels ...
Source: Biochimica et Biophysica Acta - March 7, 2018 Category: Biochemistry Authors: Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A Tags: Biochim Biophys Acta Source Type: research

Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways.
Abstract Taxanes can induce drug resistance by increasing signalling pathways such as PI3K/Akt and ERK, which promote survival and cell growth in human cancer cells. We have previously shown that long chain n-3 polyunsaturated fatty acids, such as docosahexaenoic acid (DHA, 22:6n-3) decrease resistance of experimental mammary tumors to anticancer drugs. Our objective was to determine whether DHA could increase tumor sensitivity to docetaxel by down-regulating these survival pathways. In docetaxel-treated MDA-MB-231 cells, phosphorylated-ERK1/2 levels were increased by 60% in membrane and nuclear compartments, comp...
Source: Biochimica et Biophysica Acta - January 25, 2016 Category: Biochemistry Authors: Lucie C, Goupille C, Charly B, Michelle P, Isabelle D, Cyrille G, Philippe B, Stephan C, Karine M Tags: Biochim Biophys Acta Source Type: research

Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade.
In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). BLT2 depletion with siRNA clearly abolished the chemoresistance to cisplatin in SK-OV-3 ovarian cancer cells and further increased cell sensitivity to cisplatin chemotherapy by down-regulating the 'STAT-3-IL-6' cascade. Enlarged tumor formatio...
Source: Biochimica et Biophysica Acta - November 17, 2015 Category: Biochemistry Authors: Park J, Park SY, Kim JH Tags: Biochim Biophys Acta Source Type: research