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IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth
In this study, we identified the regulatory targets of IGF2BP3 in breast cancer MDA-MB-231 cells using RNA immunoprecipitation sequencing (RIP-seq) and high-throughput RNA-sequencing (RNA-seq). We discovered that these targets were enriched in the inflammatory response, endoplasmic reticulum stress, cell cycle, and cancer-related pathways, providing a new perspective for better understanding the functional mechanisms of IGF2BP3. Moreover, we identified that the epidermal growth factor receptor (EGFR), a downstream target, is regulated by IGF2BP3. IGF2BP3 binds to and protects EGFR mRNA from degradation and facilitates cell...
Source: Biochimica et Biophysica Acta - July 20, 2023 Category: Biochemistry Authors: Xintao Jing Cong Han Qian Li Fang Li Jinyuan Zhang Qiuyu Jiang Fei Zhao Chen Guo Jinfeng Chen Ting Jiang Xiaofei Wang Yanke Chen Chen Huang Source Type: research

Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF- α secretion
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 22:166472. doi: 10.1016/j.bbadis.2022.166472. Online ahead of print.ABSTRACTDuring the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. We first demonstrated that DENV-3 infection down-regulated the expression of IRS-1. In vitro, treatment of HepG2 cells with TNF-α inhibitors and siRNA proved that after DENV-3 infection in HepG2 cell...
Source: Biochimica et Biophysica Acta - June 25, 2022 Category: Biochemistry Authors: Xuling Liu Zuxin Liang Hongwei Duan Jianhai Yu Zhiran Qin Jingshu Li Li Zhu Qinghua Wu Weiwei Xiao Chenguang Shen Chengsong Wan Kefeng Wu Hua Ye Bao Zhang Wei Zhao Source Type: research

Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production
Biochim Biophys Acta Mol Basis Dis. 2021 Aug 26:166261. doi: 10.1016/j.bbadis.2021.166261. Online ahead of print.ABSTRACTRapamycin insensitive companion of mechanistic target of Rapamycin (Rictor), the key component of mTOR complex 2 (mTORC2), controls both β-cell proliferation and function. We sought to study whether long chain acyl-CoA synthetase 4 (Acsl4) worked downstream of Rictor/mTORC2 to maintain β-cell functional mass. We found Acsl4 was positively regulated by Rictor at transcriptional and posttranslational levels in mouse β-cell. Infecting adenovirus expressing Acsl4 in β-cell-specific-Rictor-knockout (βRic...
Source: Biochimica et Biophysica Acta - August 29, 2021 Category: Biochemistry Authors: Canqi Cui Tingting Li Yun Xie Jie Yang Chenyang Fu Yixuan Qiu Linyan Shen Qicheng Ni Qidi Wang Aifang Nie Guang Ning Weiqing Wang Yanyun Gu Source Type: research

Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy.
Abstract Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine whether its function is mediated by the activation of autophagy. Here, we show that EPO decreased hepatic lipid content significantly in vivo and in vitro. Furthermore, EPO/EPO receptor (EPOR) signalling induced autophagy activation in hepatocy...
Source: Biochimica et Biophysica Acta - March 6, 2018 Category: Biochemistry Authors: Hong T, Ge Z, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D, Bi Y Tags: Biochim Biophys Acta Source Type: research

The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.
In conclusion, we have identified a new candidate, the E3 ubiquitin ligase HECTD1, that may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I. The exact mechanism by which this ligase affects this pathway remains to be elucidated. PMID: 29306077 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 3, 2018 Category: Biochemistry Authors: Aleidi SM, Yang A, Sharpe LJ, Rao G, Cochran BJ, Rye KA, Kockx M, Brown AJ, Gelissen IC Tags: Biochim Biophys Acta Source Type: research

Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGI α signaling pathways.
Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways. Biochim Biophys Acta. 2017 Mar 02;: Authors: Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, Angielski S, Piwkowska A Abstract Podocytes are dynamic polarized cells on the surface of glomerular capillaries and an essential component of the glomerular filtration barrier. Insulin increases the activation of protein kinase G type Iα (PKGIα) subunits, leading to podocyte dysfunction. In addition, accumulating evidence suggests that TRPC6 channels are crucial mediator...
Source: Biochimica et Biophysica Acta - March 1, 2017 Category: Biochemistry Authors: Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, Angielski S, Piwkowska A Tags: Biochim Biophys Acta Source Type: research

S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
CONCLUSIONS: Anthrax infection results in S-nitrosylation of multiple host proteins, including Prx1. The nitrosylation-dependent decrease in peroxidase activity of Prx1 and increase in its chaperone activity is one factor contributing to enhancing infected cell viability. GENERAL SIGNIFICANCE: These results provide a new venue of mechanistic investigation for inhalational anthrax that could lead to novel and potentially effective countermeasures. PMID: 27612662 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - September 6, 2016 Category: Biochemistry Authors: Chung MC, Alem F, Hamer SG, Narayanan A, Shatalin K, Bailey C, Nudler E, Hakami RM Tags: Biochim Biophys Acta Source Type: research

TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line.
In conclusion, this study demonstrates for the first time the expression of TRPV6 in INS-1E cells and rat pancreatic beta cells and describes its role in modulating calcium signaling, beta cell proliferation and insulin mRNA expression. In contrast, TRPV6 fails to influence insulin secretion. PMID: 26384871 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - September 16, 2015 Category: Biochemistry Authors: Skrzypski M, Khajavi N, Mergler S, Szczepankiewicz D, Kołodziejski PA, Metzke D, Wojciechowicz T, Billert M, Nowak KW, Strowski MZ Tags: Biochim Biophys Acta Source Type: research

Insulin increases glomerular filtration barrier permeability through PKGIα-dependent mobilization of BKCa channels in cultured rat podocytes.
Abstract Podocytes are highly specialized cells that wrap around glomerular capillaries and comprise a key component of the glomerular filtration barrier. They are uniquely sensitive to insulin; like skeletal muscle and fat cells, they exhibit insulin-stimulated glucose uptake and express glucose transporters. Podocyte insulin signaling is mediated by protein kinase G type I (PKGI), and it leads to changes in glomerular permeability to albumin. Here, we investigated whether large-conductance Ca(2+)-activated K(+) channels (BKCa) were involved in insulin-mediated, PKGIα-dependent filtration barrier permeability. I...
Source: Biochimica et Biophysica Acta - May 4, 2015 Category: Biochemistry Authors: Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M Tags: Biochim Biophys Acta Source Type: research