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Source: Biochimica et Biophysica Acta
Drug: Velcade

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Total 2 results found since Jan 2013.

BDNF/TrkB confers bortezomib resistance in multiple myeloma by inducing BRINP3
CONCLUSIONS: BDNF/TrkB enhanced downstream pathway expression of phosphorylation STAT3 and BRINP3 molecules, promoting RPMI 8226/BTZ cell proliferating and survival.GENERAL SIGNIFICANCE: These data place BDNF/TrkB at the top of a pSTAT3-BRINP3 survival pathway and link adaptability to BTZ resistant conditions in MM disease.PMID:36565997 | DOI:10.1016/j.bbagen.2022.130299
Source: Biochimica et Biophysica Acta - December 24, 2022 Category: Biochemistry Authors: Li Bao Yutong Wang Minqiu Lu Lei Shi Bin Chu Shan Gao Source Type: research