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Highly Efficient Photocontrolled Targeted Delivery of siRNA by a Cyclodextrin-Based Supramolecular Nanoassembly
In this study, we fabricated a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group.This nanoassembly can bind with siRNA... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 29, 2020 Category: Chemistry Authors: Feng-Qing Li Source Type: research

Biological Stability and Activity of siRNA in Ionic Liquids
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC05086J, CommunicationRomiza Mazid, Upulie Divisekera, Wenjuan Yang, Vijayaraghavan Ranganathan, Doug MacFarlane, Christina Cortez-Jugo, Wenlong Cheng: Small interfering RNA (siRNA) is extremely promising as a therapeutic due to its efficient and specific gene silencing in both in vitro and in vivo studies. However, siRNAs are...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 5, 2014 Category: Chemistry Authors: Romiza Mazid Source Type: research

Multivalent Comb-Type Aptamer-siRNA Conjugates for Efficient and Selective Intracellular Delivery
In this study, a simple, efficient, and selective intracellular delivery strategy for RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 8, 2014 Category: Chemistry Authors: HYUNDONG YOO Source Type: research