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Source: Journal of Cellular Physiology
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Total 57 results found since Jan 2013.
miR ‐150 might inhibit cell proliferation and promote cell apoptosis by targeting LMO4 in Burkitt lymphoma
This study aimed at investigating the effect of microRNA ‐150 (miR‐150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR‐150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibi tor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Cells were viewed by fluorescence microscope and transfection efficiency was evaluated through fluorescent cell percentage. Quantitative real‐time polym...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Dandan Zhang,
Yanshuan Wei,
Jun Zhou,
Guannan Wang,
Lin Xiao,
Jingjing Xu,
Na Wei,
Wencai Li,
Mingzhi Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia
This study enriches our basic knowledge for further understanding the biological behaviors of osteocytes, and is also helpful for providing a more comprehensive mechanistic understanding of the effect of electromagnetic stimulation on bone and relevant skeletal diseases (e.g., bone fractu re and osteoporosis). AbstractGrowing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and p...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Pan Wang,
Chi Tang,
Junjie Wu,
Yuefan Yang,
Zedong Yan,
Xiyu Liu,
Xi Shao,
Mingming Zhai,
Jie Gao,
Shengru Liang,
Erping Luo,
Da Jing Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR ‐181b/SIRT1/HO‐1 signaling
This study aimed to investigate the role and underlying mechanism of LA in the abdominal aortic aneurysm (AAA). AAA model was established by continuous infusion of 1000 ng/kg/min of angiotensin II (AngII) in ApoE‐/‐ mice for 4 weeks. At 7 days before AngII administration, 5 mg/kg/day or 10 mg/kg/day of LA was intraperitoneally administered to mice and continued for 4 weeks. The characteristics and quantification of AAAs were determined in situ. Real‐time PCR or western blot was used to measure mRNA or protein levels of matrix metalloproteinase 2 and matrix metal loproteinase 9; pro‐inflammatory cytokines tum...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Xuhui Hou,
Songbai Yang,
Yan Zheng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effects of microRNA ‐217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4‐induced liver injury by targeting NAT2
This study aims to explore the effects of miR ‐217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)‐induced liver injury. Rat models of CCL4‐induced liver injury were established. Healthy Wistar rats were randomized into the normal, blank, negative control (NC), microRNA‐217 (miR ‐217) mimic, miR‐217 inhibitor, small interfering RNA (siRNA)‐N‐acetyltransferase 2 (NAT2), and miR‐217 inhibitor + siRNA‐NAT2 groups. NAT2 activity was evaluated with reversed‐phase high‐performance liquid chromatographic method. Immunohistochemistry was used t...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Cheng ‐Liang Yang,
Xiao‐Li Zheng,
Ke Ye,
Ya‐Nan Sun,
Yu‐Fei Lu,
Hong Ge,
Hui Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Increased N6 ‐Methyladenosine causes infertility is associated with FTO expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 31, 2018 Category: Cytology Authors: Chenyue Ding, Qinyan Zou, Jie Ding, Mingfa Ling, Wei Wang, Hong Li, Boxian Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Calcium ‐sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 18, 2018 Category: Cytology Authors: Amanda D'Espessailles, Yuly A Mora, Cecilia Fuentes, Mariana Cifuentes Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ADAM17 Participates in the Protective Effect of Paeoniflorin on Mouse Brain Microvascular Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Haifang Wang, Shuhui Ma, Jing Li, Miaomiao Zhao, Xueping Huo, Jingying Sun, Lijun Sun, Jun Hu, Qinshe Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Protective effect of epigenetic silencing of CyclinD1 against spinal cord injury using bone marrow ‐derived mesenchymal stem cells in rats
Conclusion: Our study provides evidence that epigenetic silencing of CyclinD1 using BMSCs might accelerate the repair of SCI in rats. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Yuan Wang, Qing ‐Jie Kong, Jin‐Chuan Sun, Xi‐Ming Xu, Yong Yang, Ning Liu, Jian‐Gang Shi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
FGF ‐2 promotes osteocyte differentiation through increased E11/podoplanin expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Ekele Ikpegbu, Lena Basta, Dylan N. Clements, Robert Fleming, Tonia L. Vincent, David J. Buttle, Andrew A. Pitsillides, Katherine A. Staines, Colin Farquharson Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Inhibition of HSP90 α protects cultured neurons from oxygen‐glucose deprivation induced necroptosis by decreasing RIP3 expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - November 20, 2017 Category: Cytology Authors: Zhen Wang, Li ‐min Guo, Yong Wang, Hong‐kang Zhou, Shu‐chao Wang, Dan Chen, Ju‐fang Huang, Kun Xiong Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
MicroRNA ‐497 Accelerates Apoptosis While Inhibiting Proliferation, Migration, and Invasion through negative regulation of the MAPK/ERK signaling pathway via RAF‐1
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - November 18, 2017 Category: Cytology Authors: Ling Tao, Xia Li, Na ‐Na Han, Qi Zhou, Zhi‐Le Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The MIP ‐1α autocrine loop contributes to decreased sensitivity to anticancer drugs
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - October 23, 2017 Category: Cytology Authors: Masanobu Tsubaki, Tomoya Takeda, Yoshika Tomonari, Kenji Mashimo, Yu ‐ichi Koumoto, Sachi Hoshida, Tatsuki Itoh, Motohiro Imano, Takao Satou, Katsuhiko Sakaguchi, Shozo Nishida Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Synergistic effect of HIF ‐1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - October 14, 2017 Category: Cytology Authors: Ya ‐Fang Chen, Sudhir Pandey, Cecilia Hsuan Day, Yu‐Feng Chen, Ai‐Zhi Jiang, Tsung‐Jung Ho, Ray‐Jade Chen, Vijaya PadmaViswanadha, Wei‐Wen Kuo, Chih‐Yang Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
FHOD1 regulates cytoplasmic actin ‐based spindle migration for mouse oocyte asymmetric cell division
This study is aimed at exploring the roles of FHOD1 during the mammalian oocyte maturation. Immunofluorescent staining showed that FHOD1 was restricted to the nucleus in germinal vesicle (GV) stage of the oocytes, after the GV breakdown FHOD1 was primarily located at two poles of the spindle at both metaphase I and metaphase II stages. Knockdown of FHOD1 by siRNA injection did not affect polar body extrusion but generated the large polar bodies. In addition, we observed the spindle migration failure in metaphase I oocytes, with a large number of meiotic spindles anchoring in the center of cytoplasm. The expression level of...
Source: Journal of Cellular Physiology - July 14, 2017 Category: Cytology Authors: Meng ‐Hao Pan, Fei Wang, Yujie Lu, Feng Tang, Xing Duan, Yu Zhang, Bo Xiong, Shao‐Chen Sun Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Hypoxia ‐induced apoptosis of mouse spermatocytes is mediated by HIF‐1α through a death receptor pathway and a mitochondrial pathway
In conclusion, our data suggest that the death receptor pathway and mitochondrial pathway, which are likely mediated by HIF‐1α, contribute to hypoxia‐induced GC‐2 cell apoptosis. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - April 26, 2017 Category: Cytology Authors: Jun Yin, Bing Ni, Wei ‐gong Liao, Yu‐qi Gao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
