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Source: Journal of Cellular Physiology
Drug: Celebrex
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Sphingosine‐1‐phosphate mediates COX‐2 expression and PGE2/IL‐6 secretion via c‐Src‐dependent AP‐1 activation
Sphingosine‐1‐phosphate (S1P) has been shown to regulate cyclooxygenase‐2 (COX‐2)/prostaglandin E2 (PGE2) expression and IL‐6 secretion in various respiratory diseases. However, the mechanisms underlying S1P‐induced COX‐2 expression and PGE2 production in human tracheal smooth muscle cells (HTSMCs) remain unclear. Here we demonstrated that S1P markedly induced COX‐2 expression. S1P also induced PGE2 and IL‐6 secretion which were reduced by the inhibitors of COX‐2 (NS‐398 and celecoxib). Pretreatment with the inhibitor of S1PR1 (W123), S1PR3 (CAY10444), c‐Src (PP1), PYK2 (PF431396), MEK1/2 (U0126), p...
Source: Journal of Cellular Physiology - September 9, 2014 Category: Cytology Authors: Chih‐Kai Hsu, I‐Ta Lee, Chih‐Chung Lin, Li‐Der Hsiao, Chuen‐Mao Yang Tags: Original Research Article Source Type: research
