Filtered By:
Source: Journal of Cellular Physiology
Drug: Zocor
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1 results found since Jan 2013.
RhoA‐Mediated Inhibition of Vascular Endothelial Cell Mobility: Positive Feedback Through Reduced Cytosolic p21 and p27
In this study, we investigated the mechanisms of 3MC‐mediated downregulation of cytosolic p21/ p27, and the effects of 3MC on RhoA activation and cell migration, in mouse cerebral vascular endothelial cells (MCVECs). Our results indicated that 3MC reduced the phosphorylation of p21/p27 through AhR/RhoA/PTEN‐mediated PI3K/Akt inactivation, which reduced cytosolic p21/p27 retention, causing RhoA activation through positive feedback. Downregulation of p21/p27 by siRNA, and cytosolic p21/p27 by the nuclear export blocker leptomycin B, further reduced cell migration in the 3MC‐treated cells. Reduced cytosolic p21/p27 expr...
Source: Journal of Cellular Physiology - February 18, 2014 Category: Cytology Authors: Yung‐Ho Hsu, Chih‐Cheng Chang, Nian‐Jie Yang, Yi‐Hsuan Lee, Shu‐Hui Juan Tags: Original Research Article Source Type: research
