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Source: Journal of Cellular Physiology
Cancer: Leukemia
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Total 2 results found since Jan 2013.
The Association between p38 MAPK‐Mediated TNF‐α/TNFR2 Up‐Regulation and 2‐(4‐Aminophenyl)‐7‐Methoxybenzothiazole‐Induced Apoptosis in Human Leukemia U937 Cells
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Source: Journal of Cellular Physiology - June 8, 2015 Category: Cytology Authors: Chia‐Hui Huang, Ying‐Jung Chen, Tzu‐Yu Chao, Wen‐Hsin Liu, Jung‐Jung Changchien, Wan‐Ping Hu, Long‐Sen Chang Tags: Original Research Article Source Type: research
ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells
This study was performed using established cell lines HL60 and U937, and primary cultures of blasts from 10 patients with ML. We found that ERK5 and its direct downstream target transcription factor MEF2C are upregulated by 1,25D in parallel with monocytic differentiation. Further, inhibition of ERK5 activity by specific pharmacological agents BIX02189 and XMD8‐92 alters the phenotype of these cells by reducing the abundance of the VDD‐induced surface monocytic marker CD14, and concomitantly increasing surface expression of the general myeloid marker CD11b. Similar results were obtained when the expression of ERK5 was ...
Source: Journal of Cellular Physiology - November 22, 2013 Category: Cytology Authors: Xuening Wang, Stella Pesakhov, Jonathan S Harrison, Michael Danilenko, George P Studzinski Tags: Original Research Article Source Type: research
