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Source: Molecular Carcinogenesis
Nutrition: Diets
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Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
This study found that submicromolar concentrations of urolithin A, a major polyphenol metabolite, induced autophagy in SW620 colorectal cancer (CRC) cells. Exposure to urolithin A also dose‐dependently decreased cell proliferation, delayed cell migration and decreased matrix metalloproteinas‐9 (MMP‐9) activity. In addition, inhibition of autophagy by Atg5‐siRNA, caspases by Z‐VAD‐FMK suppressed urolithin A‐ stimulated cell death and anti‐metastatic effects. Micromolar urolithin A concentrations induced both autophagy and apoptosis. Urolithin A suppressed cell cycle progression and inhibited DNA synthesis. T...
Source: Molecular Carcinogenesis - October 4, 2017 Category: Molecular Biology Authors: Wenhua Zhao, Fengqiang Shi, Zhikun Guo, Jiaojie Zhao, Xueying Song, Hua Yang Tags: RESEARCH ARTICLE Source Type: research
