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TNFAIP8 regulates Hippo pathway through interacting with LATS1 to promote cell proliferation and invasion in lung cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - September 19, 2017 Category: Molecular Biology Authors: Yong Han, ZhongPing Tang, Yue Zhao, Qingchang Li, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research

p0071 interacts with E ‐cadherin in the cytoplasm so as to promote the invasion and metastasis of non‐small cell lung cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - September 12, 2017 Category: Molecular Biology Authors: Huanyu Zhao, Di Zhang, Lianhe Yang, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research

Lasp2 enhances tumor invasion via facilitating phosphorylation of FAK and predicts poor overall survival of non ‐small cell lung cancer patients
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - July 1, 2017 Category: Molecular Biology Authors: Xiupeng Zhang, Lin Cai, Haijing Zhou, Yang Liu, Chuifeng Fan, Liang Wang, Ailin Li, Yuan Miao, Qingchang Li, Xueshan Qiu, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research

Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer
This study aimed at increasing the knowledge on the involvement of adhesion molecules in lung cancer progression by studying the regulation and role of NFASC in non‐small cell lung cancer (NSCLC). Here, copy number variations in the NFASC gene were analyzed in tumor and non‐tumorous lung tissues of 204 NSCLC patients. Frequent gene amplifications (OR = 4.50, 95%CI: 2.27‐8.92, P ≤ 0.001) and increased expression of NFASC (P = 0.034) were identified in tumors of NSCLC patients. Furthermore, molecular mechanisms of NFASC in lung cancer progression were evaluated by investigating the effects of NFASC silenc...
Source: Molecular Carcinogenesis - May 2, 2017 Category: Molecular Biology Authors: Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny Tags: RESEARCH ARTICLE Source Type: research

Copy number variation, increased gene expression and molecular mechanisms of Neurofascin in lung cancer
This study aimed at increasing the knowledge on the involvement of adhesion molecules in lung cancer progression by studying the regulation and role of NFASC in non‐small cell lung cancer (NSCLC). Here, copy number variations in the NFASC gene were analyzed in tumor and non‐tumorous lung tissues of 204 NSCLC patients. Frequent gene amplifications (OR = 4.50, 95% CI: 2.27‐8.92, P ≤ 0.001) and increased expression of NFASC (P = 0.034) were identified in tumors of NSCLC patients. Furthermore, molecular mechanisms of NFASC in lung cancer progression were evaluated by investigating the effects of NFASC silencing...
Source: Molecular Carcinogenesis - April 18, 2017 Category: Molecular Biology Authors: Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny Tags: RESEARCH ARTICLE Source Type: research

Kctd20 promotes the development of non ‐small cell lung cancer through activating Fak/AKT pathway and predicts poor overall survival of patients
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - April 11, 2017 Category: Molecular Biology Authors: Xiupeng Zhang, Haijing Zhou, Lin Cai, Chuifeng Fan, Yang Liu, Liang Wang, Qingchang Li, Yuan Miao Tags: RESEARCH ARTICLE Source Type: research

A Zbtb7a proto‐oncogene as a novel target for miR‐125a
In our previous study, we showed that miR‐125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR‐125a knockout mice overexpressed WT1 and developed myeloproliferative disease. It had been also reported that miR‐125a is downregulated in leukemia and various types of solid tumors such as lung cancers, suggesting its tumor suppressor function. Therefore, it is important to elucidate what is target(s) of miR‐125a for understan...
Source: Molecular Carcinogenesis - December 29, 2015 Category: Molecular Biology Authors: Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji Tags: Research Article Source Type: research

A Zbtb7a proto ‐oncogene as a novel target for miR‐125a
In our previous study, we showed that miR‐125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR‐125a knockout mice overexpressed WT1 and developed myeloproliferative disease. It had been also reported that miR‐125a is downregulated in leukemia and various types of solid tumors such as lung cancers, suggesting its tumor suppressor function. Therefore, it is important to elucidate what is target(s) of miR‐125a for understan...
Source: Molecular Carcinogenesis - December 28, 2015 Category: Molecular Biology Authors: Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji Tags: Article Source Type: research

Zbed3 contributes to malignant phenotype of lung cancer via regulating β‐catenin and P120‐catenin 1
Our previous studies indicate that abnormal expression of several Wnt signaling molecules including Axin, Dvl and β‐catenin are involved in proliferation, invasion and metastasis of lung cancer. Zbed3 was found to inhibit function of Axin‐GSK3β complex and thus lead to accumulation of β‐catenin in NIH3T3 and HEK293T cells. However its function in malignant tumors is largely unknown. Here we investigate the clinico‐pathological significance of Zbed3 expression and its function in non‐small cell lung cancer. We use immunohistochemistry and Western blotting to examine Zbed3 expression in non‐small cell lung can...
Source: Molecular Carcinogenesis - September 27, 2014 Category: Molecular Biology Authors: Chuifeng Fan, Guiyang Jiang, Xiupeng Zhang, Yuan Miao, Xuyong Lin, Lan Luan, Zhonghai Xu, Yijun Zhang, Huanyu Zhao, Di Liu, Enhua Wang Tags: Research Article Source Type: research

Src mediates extracellular signal‐regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non‐small cell lung cancer cell lines
Aberrant Na+/K+‐ATPases (NKA) expression is closely related to the incidence and development of cancer, making NKA targeted cancer therapy more intriguing. Cardiac glycosides (CGs) belong to NKA inhibitors and possess potent anti‐cancer properties in many cancers. Our previous work demonstrates that CGs family member digoxin or ouabain induces autophagic cell death in human non‐small cell lung cancer (NSCLC) cell lines through regulation of both mammalian target of rapamycin and extracellular signal‐regulated kinase 1/2 (ERK1/2) pathway. However, what acts as an upstream regulator of ERK1/2 activation during autoph...
Source: Molecular Carcinogenesis - March 1, 2014 Category: Molecular Biology Authors: Yan Wang, Yuechen Zhan, Rong Xu, Rongguang Shao, Jiandong Jiang, Zhen Wang Tags: Research Article Source Type: research

Involvement of RECK in gambogic acid induced anti‐invasive effect in A549 human lung carcinoma cells
Gambogic acid (GA), a xanthone derived from the resin of the Garcinia hanburyi, has been demonstrated possessing anti‐metastatic activity in vitro and in vivo. Reversion‐inducing cysteine‐rich protein with Kazal motifs (RECK), a membrane‐anchored glycoprotein negatively regulating matrix metalloproteinases (MMPs), plays an important role in tumor invasion and metastasis. The present study investigates the regulatory effect of GA on RECK expression and the role of RECK in GA‐induced anti‐invasion in A549 human lung cancer cells. Our results showed that GA dose‐dependently inhibited cell invasion and suppressed...
Source: Molecular Carcinogenesis - February 1, 2014 Category: Molecular Biology Authors: Qi Qi, Na Lu, Chenglin Li, Jie Zhao, Wei Liu, Qidong You, Qinglong Guo Tags: Research Article Source Type: research

Thromboxane A2 receptor‐mediated release of matrix metalloproteinase‐1 (MMP‐1) induces expression of monocyte chemoattractant protein‐1 (MCP‐1) by activation of protease‐activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells
Abstract Matrix metalloproteinases (MMPs) and monocyte chemoattractant protein‐1 (MCP‐1, CCL2) are known to be upregulated in many tumors. Their roles in tumor invasion and metastasis are being uncovered. How they are related to each other and involved in tumor progression remains to be determined. Earlier it was reported that I‐BOP‐initiated activation of thromboxane A2 receptor (TP) induced the release of MMP‐1, MMP‐3, and MMP‐9 from lung cancer A549 cells overexpressing TPα (A549‐TPα). Herein it was found that MMP‐1, but not MMP‐3 or MMP‐9, induced the expression of MCP‐1 in A549 cells. Conditi...
Source: Molecular Carcinogenesis - March 8, 2013 Category: Molecular Biology Authors: Xiuling Li, Hsin‐Hsiung Tai Tags: Research Article Source Type: research

Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation
Abstract The beneficial effects of omega‐3 fatty acids are believed to be due in part to selective alteration of arachidonate metabolism that involves cyclooxygenase (COX) enzymes. Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non‐small cell lung cancer A549 (COX‐2 over‐expressing) and H1299 (COX‐2 null) cells as well as their xenograft models. While EPA inhibited 50% of proliferation of A549 cells at 6.05 µM, almost 80 µM of EPA was needed to reach similar levels of inhibition of H1299 cells. The formation of prostaglandin (PG)E3 in A549 cells was almost three...
Source: Molecular Carcinogenesis - January 31, 2013 Category: Molecular Biology Authors: Peiying Yang, Carrie Cartwright, Diana Chan, Jibin Ding, Edward Felix, Yong Pan, Jihai Pang, Patrea Rhea, Keith Block, Susan M. Fischer, Robert A. Newman Tags: Research Article Source Type: research