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Source: Molecular Carcinogenesis
Cancer: Epithelial Cancer
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Total 14 results found since Jan 2013.
CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture
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Source: Molecular Carcinogenesis - June 15, 2017 Category: Molecular Biology Authors: Antonella Muscella, Carla Vetrugno, Santo Marsigliante Tags: RESEARCH ARTICLE Source Type: research
(E) ‐2‐methoxy‐4‐(3‐(4‐methoxyphenyl)prop‐1‐en‐1‐yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3
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Source: Molecular Carcinogenesis - March 8, 2017 Category: Molecular Biology Authors: Jie Zheng, Dong Ju Son, Hye Lim Lee, Hee Pom Lee, Tae Hoon Kim, Jung Heun Joo, Young Wan Ham, Wun Jae Kim, Jae Kyung Jung, Sang ‐Bae Han, Jin Tae Hong Tags: RESEARCH ARTICLE Source Type: research
Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial ‐mesenchymal transition (EMT) markers
This study aims to demonstrate expression and potential role of NR5A2 in pancreatic cancer. NR5A2 expression was quantified in resected pancreatic ductal adenocarcinomas and the normal adjacent tissues of 134 patients by immunohistochemistry. The intensity and extent of NR5A2 staining was quantified and analyzed in association with overall survival (OS). The impact of NR5A2 knockdown on pancreatic cancer stem cell (CSC) properties and epithelial‐mesenchymal transition (EMT) markers was examined in cancer cells using RT‐PCR and Western Blot. NR5A2 was overexpressed in pancreatic tumors, the IHC‐staining H score (mean...
Source: Molecular Carcinogenesis - December 19, 2016 Category: Molecular Biology Authors: Zhaofan Luo, Yanan Li, Zuo Mingxin, Chang Liu, Dong Yan, Huamin Wang, Donghui Li Tags: Research Article Source Type: research
S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway
An elevated level of S100A6 is associated with poor outcomes of many tumor types, but, how S100A6 contributes to nasopharyngeal carcinoma (NPC) progression remains unknown. Here, we investigated the expression and prognostic significance of S100A6 in NPC and explored the molecular mechanisms underlying the role of S100A6 in NPC development. The results showed that S100A6 was markedly up‐regulated in NPC tissues and cell lines compared to paired peritumoral normal tissues and a normal nasopharyngeal epithelial cell line, respectively. In tissues from 92 NPC patients, high S100A6 expression was associated with advanced N...
Source: Molecular Carcinogenesis - September 26, 2016 Category: Molecular Biology Authors: Anchuan Li, Dingbo Shi, Benhua Xu, Jingshu Wang, Yan ‐Lai Tang, WeiWei Xiao, Guanzhu Shen, Wuguo Deng, Chong Zhao Tags: Research Article Source Type: research
S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signalling pathway
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - September 5, 2016 Category: Molecular Biology Authors: Anchuan Li, Dingbo Shi, Benhua Xu, Jingshu Wang, Yan ‐Lai Tang, WeiWei Xiao, Guanzhu Shen, Wuguo Deng, Chong Zhao Tags: Research Article Source Type: research
TGFβ induces epithelial‐mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways
The epithelial‐mesenchymal transition (EMT) is a crucial process in tumour progression, by which epithelial cells acquire a mesenchymal phenotype, increasing its motility and the ability to invade distant sites. Here, we describe the molecular mechanisms by which V600EBRAF, TGFβ and the Src/FAK complex cooperatively regulate EMT induction and cell motility of anaplastic thyroid cancer cells. Analysis of EMT marker levels reveals a positive correlation between TGFβ and Snail expression, with a concomitant downregulation of E‐cadherin, accompanied by an increase of cell migration and invasion. Furthermore, we show that...
Source: Molecular Carcinogenesis - September 22, 2015 Category: Molecular Biology Authors: Pablo Baquero, Eva Jiménez‐Mora, Adrián Santos, Marina Lasa, Antonio Chiloeches Tags: Research Article Source Type: research
TGF β induces epithelial‐mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways
The epithelial‐mesenchymal transition (EMT) is a crucial process in tumour progression, by which epithelial cells acquire a mesenchymal phenotype, increasing its motility and the ability to invade distant sites. Here, we describe the molecular mechanisms by which V600EBRAF, TGFβ and the Src/FAK complex cooperatively regulate EMT induction and cell motility of anaplastic thyroid cancer cells. Analysis of EMT marker levels reveals a positive correlation between TGFβ and Snail expression, with a concomitant downregulation of E‐cadherin, accompanied by an increase of cell migration and invasion. Furthermore, we show that...
Source: Molecular Carcinogenesis - September 20, 2015 Category: Molecular Biology Authors: Pablo Baquero, Eva Jim énez‐Mora, Adrián Santos, Marina Lasa, Antonio Chiloeches Tags: Article Source Type: research
Antitumor effects of interleukin‐6 (IL‐6)/interleukin‐6 receptor (IL‐6R) signaling pathway inhibition in clear cell carcinoma of the ovary
In this study, we aim to clarify whether IL‐6/IL‐6R mediated signaling pathway could have clinical relations with CCC and to evaluate inhibitory effects of the pathway on CCC carcinogenesis. A total of 84 CCC cases collected from primary surgical specimens were evaluated by the immunohistochemical analysis for IL‐6R and phosphorylated Stat3 (pStat3), and we found that high IL‐6R expression correlated with poor patient survival both by the univariate and multivariate analyses, suggesting that IL‐6/IL‐6R signaling pathway could be implicated in the progression of CCC. We further investigated the effects of IL‐6...
Source: Molecular Carcinogenesis - April 10, 2015 Category: Molecular Biology Authors: Nozomu Yanaihara, Yukihiro Hirata, Noriko Yamaguchi, Yukiko Noguchi, Misato Saito, Chie Nagata, Satoshi Takakura, Kyosuke Yamada, Aikou Okamoto Tags: Research Article Source Type: research
Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF‐β pathway
Embigin is a member of the immunoglobulin superfamily and encodes a transmembrane glycoprotein. There have been reports of Embigin involvement in neuromuscular junction formation and plasticity; however, the molecular functions of Embigin in other organs are unknown. Our aim was to investigate the possible role of Embigin in pancreatic cancer. In pancreatic ductal adenocarcinoma tissues, Embigin expression was higher than that in normal pancreatic tissues. Immunohistochemical analysis revealed expression of Embigin in pancreatic cancer cells, as well as expression of monocarboxylate transporter 2 (MCT2) in cancer tissues. ...
Source: Molecular Carcinogenesis - March 15, 2015 Category: Molecular Biology Authors: Dawoon E. Jung, Jeong Mi Kim, Chanyang Kim, Si Young Song Tags: Research Article Source Type: research
Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial‐to‐mesenchymal transition (EMT) in bladder cancer
Activation of the sonic hedgehog (Shh) signaling pathway controls tumorigenesis in a variety of cancers. Here, we show a role for Shh signaling in the promotion of epithelial‐to‐mesenchymal transition (EMT), tumorigenicity, and stemness in the bladder cancer. EMT induction was assessed by the decreased expression of E‐cadherin and ZO‐1 and increased expression of N‐cadherin. The induced EMT was associated with increased cell motility, invasiveness, and clonogenicity. These progression relevant behaviors were attenuated by treatment with Hh inhibitors cyclopamine and GDC‐0449, and after knockdown by Shh‐siRNA,...
Source: Molecular Carcinogenesis - March 1, 2015 Category: Molecular Biology Authors: S.S. Islam, R.B. Mokhtari, A.S. Noman, M. Uddin, M.Z. Rahman, M.A. Azadi, A. Zlotta, T. van der Kwast, H. Yeger, W.A. Farhat Tags: Research Article Source Type: research
PTN signaling: Components and mechanistic insights in human ovarian cancer
In this study, we show that PTN is expressed, produced, and secreted in a panel of EOC cell lines. PTN levels in serous ovarian tumor tissues are on average 3.5‐fold higher relative to normal tissue and PTN is detectable in serum samples of patients with EOC. PTPRZ1 is also expressed and produced by EOC cells and is found to be up‐regulated in serous ovarian tumor tissue relative to normal ovarian surface epithelial tissue (P < 0.05). Gene silencing of PTPRZ1 in EOC cell lines using siRNA‐mediated knockdown shows that PTPRZ1 is essential for viability and results in significant apoptosis with no effect on the ...
Source: Molecular Carcinogenesis - November 21, 2014 Category: Molecular Biology Authors: Geetika Sethi, Youngjoo Kwon, Rebecca J. Burkhalter, Harsh B. Pathak, Rashna Madan, Sarah McHugh, Safinur Atay, Smruthi Murthy, Ossama W. Tawfik, Andrew K. Godwin Tags: Research Article Source Type: research
Zbed3 contributes to malignant phenotype of lung cancer via regulating β‐catenin and P120‐catenin 1
Our previous studies indicate that abnormal expression of several Wnt signaling molecules including Axin, Dvl and β‐catenin are involved in proliferation, invasion and metastasis of lung cancer. Zbed3 was found to inhibit function of Axin‐GSK3β complex and thus lead to accumulation of β‐catenin in NIH3T3 and HEK293T cells. However its function in malignant tumors is largely unknown. Here we investigate the clinico‐pathological significance of Zbed3 expression and its function in non‐small cell lung cancer. We use immunohistochemistry and Western blotting to examine Zbed3 expression in non‐small cell lung can...
Source: Molecular Carcinogenesis - September 27, 2014 Category: Molecular Biology Authors: Chuifeng Fan, Guiyang Jiang, Xiupeng Zhang, Yuan Miao, Xuyong Lin, Lan Luan, Zhonghai Xu, Yijun Zhang, Huanyu Zhao, Di Liu, Enhua Wang Tags: Research Article Source Type: research
PPARδ deficiency disrupts hypoxia‐mediated tumorigenic potential of colon cancer cells
Peroxisome proliferator‐activated receptor (PPAR) δ is highly expressed in colon epithelial cells and closely linked to colon carcinogenesis. However, the role of PPARδ in colon cancer cells in a hypoxic tumor microenvironment is not fully understood. We found that expression of the tumor‐promoting cytokines, IL‐8 and VEGF, induced by hypoxia (<1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARδ‐deficient HCT116 colon cancer cells. Consequently, PPARδ‐knockout colon cancer cells exposed to hypoxia and deferoxamine failed to stimulate endothelial cell vascularization and macrop...
Source: Molecular Carcinogenesis - March 9, 2014 Category: Molecular Biology Authors: Eunshil Jeong, Jung Eun Koo, Sang Hyeon Yeon, Mi‐Kyoung Kwak, Daniel H. Hwang, Joo Young Lee Tags: Research Article Source Type: research
MicroRNA‐106b modulates epithelial–mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
In this study, we sought to explore the role of TWIST1 in inducing EMT in representative type II EC cell lines, and to determine the miRNAs involved in regulating TWIST1 gene expression. Functional analysis suggested that TWIST1 contributes to the EMT phenotypes of EC cells, as evidenced by the acquisition of fibroblast‐like properties, enhanced invasiveness, and induction of an EN‐switch (downregulation of epithelial marker E‐cadherin and upregulation of mesenchymal marker N‐cadherin). Conversely, silencing of TWIST1 by siRNA inhibited cell invasion and the mesenchymal phenotype, which was accompanied by a reversi...
Source: Molecular Carcinogenesis - September 3, 2013 Category: Molecular Biology Authors: Peixin Dong, Masanori Kaneuchi, Hidemichi Watari, Satoko Sudo, Noriaki Sakuragi Tags: Research Article Source Type: research
