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Lupus nephritis IgG induces the expression of calcium/calmodulin‐dependent kinase type IV in podocytes and alters their function
Conclusions: LN IgG enters podocytes and upregulates CaMKIV followed by increased expression of genes known to be linked to podocyte damage and T cell activation. Targeted inhibition of CaMKIV in podocytes may prove of clinical use in patients with LN. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 4, 2015 Category: Rheumatology Authors: Kunihiro Ichinose, Takeshi Ushigusa, Ayako Nishino, Yosikazu Nakashima, Takahisa Suzuki, Yoshiro Horai, Tomohiro Koga, Shin‐ya Kawashiri, Naoki Iwamoto, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Yoko Obata, Kazuo Yamamoto, Tomoki Origuchi, Tomoya Nis Tags: Full Length Source Type: research

Macrophage Migration Inhibitory Factor Down‐Regulates the RANKL–RANK Signaling Pathway by Activating Lyn Tyrosine Kinase in Mouse Models
ConclusionOur findings indicate that the tyrosine kinase Lyn is activated when MIF binds to its receptor CD74 and its coreceptor CD44 and, in turn, down‐regulates the RANKL‐mediated signaling cascade by suppressing NF‐ATc1 protein expression through down‐regulation of AP‐1 and calcium signaling components.
Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Se Hwan Mun, Dongmyung Oh, Sun‐Kyeong Lee Tags: Bone Biology Source Type: research

Macrophage migration inhibitory factor down‐regulates the RANKL‐RANK signaling pathway by activating Lyn tyrosine kinase
Conclusions: Our findings indicate that the tyrosine kinase, Lyn, is activated when MIF binds to its receptor, CD74 and co‐receptor, CD44 and, in turn, down regulates the RANKL‐mediated signaling cascade by suppressing NFATc1 protein expression through downregulation of AP‐1 and calcium signaling components. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - May 28, 2014 Category: Rheumatology Authors: Se Hwan Mun, Dongmyung Oh, Sun‐Kyeong Lee Tags: Full Length Source Type: research