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LncRNA NEAT1 Promotes Deterioration of Hepatocellular Carcinoma Based on < b > < i > In Vitro Experiments, Data Mining, and < /i > < /b > RT-qPCR Analysis
Conclusions:NEAT1 contributes to the deterioration of HCC and provides a potential biomarker for the diagnosis and therapy of HCC.Cell Physiol Biochem 2018;48:540 –555
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

A Preliminary Investigation of PVT1 on the Effect and Mechanisms of Hepatocellular Carcinoma: Evidence from Clinical Data, a Meta-Analysis of 840 Cases, and < b > < i > In Vivo < /i > < /b > Validation
Conclusions: We hypothesized thatPVT1 could affect the biological function of HCC cells via targetingmiR-424-5p and regulatingINCENP. Focusing on the new insight of thePVT1/miR-424-5p/INCENP axis, this study provides a novel perspective for HCC therapeutic strategies.Cell Physiol Biochem 2018;47:2216 –2232
Source: Cellular Physiology and Biochemistry - July 5, 2018 Category: Cytology Source Type: research

The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III
Conclusion: EGFRvIII could induce autophagy, and CH12 treatment could improve autophagy activity in EGFRvIII-positive liver cancer cells. The combination of CH12 with an autophagy inhibitor or siRNA against key proteins in the autophagy pathway displayed more significant efficacy on EGFRvIII-positive tumor cells than monotherapy, and induced cell apoptosis.Cell Physiol Biochem 2018;46:226 –237
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling
Conclusion: Our findings indicate that hypoxia triggers ROS-mediated GLI1-dependent EMT progress and invasion of HCC cells through induction of NOX4 expression. Thus, hypoxia-driven ROS mediated non-canonical Hh signaling may play an important role in the initiation of EMT and provides a potential marker for cancer prevention and treatment.Cell Physiol Biochem 2017;44:1856 –1868
Source: Cellular Physiology and Biochemistry - December 13, 2017 Category: Cytology Source Type: research

TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/ β-Catenin Pathway
Conclusions: TLR4 can affect the expression of β-catenin and hence influence the progression of HBV-related HCC.Cell Physiol Biochem 2017;42:469 –479
Source: Cellular Physiology and Biochemistry - June 2, 2017 Category: Cytology Source Type: research

Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Conclusions: In this study, we found that radiation up-regulated the expression of ATF4. We used ATF4 knockdown and over-expression systems to show that ATF4 may play a role in radiation-induced cellular apoptosis.Cell Physiol Biochem 2017;41:784 –794
Source: Cellular Physiology and Biochemistry - February 10, 2017 Category: Cytology Source Type: research

Angiotensin II Enhances Proliferation and Inflammation through AT1/PKC/NF-κB Signaling Pathway in Hepatocellular Carcinoma Cells
Conclusions: The results propose that Ang II/AT1/PKC/NF-#x03BA;B signaling pathway is necessary for proliferation and inflammation of HCC cells, which increases our understanding of the pathogenesis and provides clues for developing new strategies against Ang II-related progress of HCC.Cell Physiol Biochem 2016;39:13-32
Source: Cellular Physiology and Biochemistry - June 20, 2016 Category: Cytology Source Type: research

Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression
Conclusion: Our findings show that PHD2 represents a potential contributing factor for HCC-associated erythrocytosis. Selective inhibition of PHD2 in HCC cells might be considered as a new way to manage erythrocytosis in HCC patients.Cell Physiol Biochem 2015;37:2257-2264
Source: Cellular Physiology and Biochemistry - December 1, 2015 Category: Cytology Source Type: research

MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma
Conclusion: HDAC9 plays an important role both as effects and targets of miR-376a.Cell Physiol Biochem 2015;35:729-739
Source: Cellular Physiology and Biochemistry - January 16, 2015 Category: Cytology Source Type: research