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Effects of the Long Non-Coding RNA HOST2 On the Proliferation, Migration, Invasion and Apoptosis of Human Osteosarcoma Cells
Conclusions: Inhibition of lnc-HOST2 could suppress the proliferation, migration, and invasion and promote the apoptosis of osteosarcoma cells.Cell Physiol Biochem 2017;43:320 –330
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II
Conclusions: These data support our hypothesis that hypoxia increases proliferation of osteosarcoma cells in an arginase II-dependent manner. We speculate that arginase II may represent a therapeutic target in osteosarcoma. Cell Physiol Biochem 2016;39:802-813
Source: Cellular Physiology and Biochemistry - July 29, 2016 Category: Cytology Source Type: research

A Single Nucleotide Polymorphism (rs1056629) in 3'-UTR of MMP-9 is Responsible for a Decreased Risk of Metastatic Osteosarcoma by Compromising its Interaction with microRNA-491-5p
Conclusion: We found that the rs1056629 polymorphism interfered with the interaction between MMP9 mRNA and miR-491 and is associated with the metastasis of OS cells.Cell Physiol Biochem 2016;38:1415-1424
Source: Cellular Physiology and Biochemistry - March 29, 2016 Category: Cytology Source Type: research

MicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16
Background: Metastasis is a leading cause of mortality for osteosarcoma (OS) patients, and its molecular pathological mechanisms remain to be elucidated. Previous studies have suggested a significant role of microRNAs (miRNAs) in the control of cancel cell migration and invasion. Methods: Real-time PCR was used to screen the differentially expressed miRNAs between OS with or without metastasis, and miR-145 underexpression was observed in metastatic OS. Luciferase assay was performed to validate the target gene. Results: Further, we identified three genes, MMP16, ADAM17 and metadherin, as possible targets of miR-145. We ide...
Source: Cellular Physiology and Biochemistry - November 25, 2015 Category: Cytology Source Type: research