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Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells
ConclusionDHA can effectively promote ferroptosis-mediated tumor killing by increasing intracellular lipid peroxidation. Both ALOX5 dependent and independent pathways are involved in DHA-FIN induced ferroptosis. And during this process, free DHA plays an important role.
Source: European Journal of Nutrition - July 9, 2022 Category: Nutrition Source Type: research

Homocysteine-induced decrease in HUVEC cells ’ resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism
ConclusionsThese data indicate that Hcy induces an increase in cellular ferritin level, and the process is mediated by alterations in Akt-FOXO3a signaling pathway.
Source: European Journal of Nutrition - March 24, 2021 Category: Nutrition Source Type: research

Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3
ConclusionT1R1/T1R3 serves as sensor of extracellular amino acids in mouse mammary epithelial cells and involved in milk protein synthesis regulation.
Source: European Journal of Nutrition - August 17, 2016 Category: Nutrition Source Type: research

High-fat diet induces cardiomyocyte apoptosis via the inhibition of autophagy
Conclusion HFD can cause cardiac injury by induction of apoptosis which is associated with autophagy dysregulation and ER stress. In addition, autophagy deficiency augments cardiac apoptosis, suggesting that autophagy serves as a pro-survival role in lipotoxic condition.
Source: European Journal of Nutrition - September 10, 2015 Category: Nutrition Source Type: research

Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway
Conclusion Suppression of the TXNIP–NLRP3 inflammasome pathway may partly contribute to the amelioration of hepatic injury during the progression of NASH by honey. Targeting hepatic TXNIP–NLRP3 inflammasome pathway is a potential therapeutic way for the prevention and treatment of NASH.
Source: European Journal of Nutrition - July 2, 2015 Category: Nutrition Source Type: research