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A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway
Conclusions and ImplicationsIDHP attenuated the cardiac fibrosis induced by isoprenaline through a NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis, induced by β‐adrenoceptor agonists.
Source: British Journal of Pharmacology - May 5, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: RESEARCH PAPER Source Type: research

IDHP Attenuates β‐Adrenergic Receptor Mediated Cardiac Fibrosis depending on NOX2/ROS/p38 Pathway
CONCLUSIONS AND IMPLICATIONSIDHP attenuates cardiac fibrosis induced by isoproterenol through NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis.
Source: British Journal of Pharmacology - March 13, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed issue Source Type: research