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Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signalling pathway via GSK‐3β inactivation
Abstract Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment‐producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in vitiligo. Therefore, in this study, we investigated the cytoprotective effects of afzelin against oxidative stress and its mechanism of action in human epidermal melanocytes. We found that afzelin significantly inhibited hydrogen peroxide‐induced cell death, cellular reactive oxygen species production and lipid peroxidation in melanocytes. In an antioxi...
Source: Experimental Dermatology - April 11, 2017 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: ORIGINAL ARTICLE Source Type: research

Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signaling pathway via GSK‐3β inactivation
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 18, 2016 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: Regular Article Source Type: research