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The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
Conclusions: Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling. This represents the first association of SgK223 with a particular human cancer, and links SgK223 with a major signaling pathway strongly implicated in PDAC progression.
Source: Molecular Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Carole TactacanYu PhuaLing LiuLuxi ZhangEmily HumphreyMark CowleyMark PineseAndrew BiankinRoger Daly Source Type: research

TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling
Background: TFAP2B is a member of the AP2 transcription factor family, which orchestrates a variety of cell processes. However, the roles of TFAP2B in regulating carcinogensis remain largely unknown. Here, we investigated the regulatory effects of TFAP2B on lung adenocarcinomas growth and identified the underlying mechanisms of actions in non-small cell lung cancer (NSCLC) cells. Methods: We first examined the expression of TFAP2B in lung cancer cell lines and tumor tissues. We also analyzed the prognostic predicting value of TFAP2B in lung adenocarcinomas. Then we investigated the molecular mechanisms by which TFAP2B knoc...
Source: Molecular Cancer - April 26, 2014 Category: Cancer & Oncology Authors: Lingyi FuKe ShiJingshu WangWangbing ChenDingbo ShiYun TianWei GuoWendan YuXiangsheng XiaoTiebang KangShusen WangWenlin HuangWuguo Deng Source Type: research

IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9
Conclusions: IL-1beta-induced p38 activation and the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in GA; this pathway may provide a novel therapeutic target for GA.
Source: Molecular Cancer - January 31, 2014 Category: Cancer & Oncology Authors: Qiaojia HuangFenghua LanXiaoting WangYinghao YuXuenong OuyangFeng ZhengJunyong HanYoudong LinYanchuan XieFeilai XieWei LiuXiaoli YangHan WangLihong DongLie WangJianming Tan Source Type: research

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
Conclusions: The importance of Src family kinases and PKCssII in the initiation of the EGFR signaling pathway in lung tumor cells was demonstrated. We conclude that phosphorylation of EGFR is mediated through PKCssII regulation of Lyn activation, and occurs in association with RACK1 and Cbp/PAG proteins. We suggest that protein complexes in cell membranes, including lipid rafts, may serve as novel targets for combination therapies with EGFR and Src Family Kinase inhibitors in lung cancer.
Source: Molecular Cancer - July 16, 2013 Category: Cancer & Oncology Authors: Parnetta SuttonJeffrey BorgiaPhilip BonomiJanet Plate Source Type: research