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Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
Conclusions: Taken together, these findings highlight mitotic kinases and, in particular, WEE1 as a rational therapeutic target for medulloblastoma.
Source: Molecular Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Peter HarrisSujatha VenkataramanIrina AlimovaDiane BirksIlango BalakrishnanBrian CristianoAndrew DonsonAdrian DubucMichael TaylorNicholas ForemanPhilip ReiganRajeev Vibhakar Source Type: research

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Conclusion: Together, our data show a novel role for the WNK1/OSR1/NKCC1 pathway in basal and TMZ-induced glioma migration, and suggest that glioma treatment with TMZ might be improved by drugs that inhibit elements of the WNK1/OSR1/NKCC1 signaling pathway.
Source: Molecular Cancer - February 20, 2014 Category: Cancer & Oncology Authors: Wen ZhuGulnaz BegumKelli PointerPaul ClarkSung-Sen YangShih-Hua LinKristopher KahleJohn KuoDandan Sun Source Type: research

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Conclusions: Our results suggest that development of inhibitors which interfere with CD44-moesin interactions may open a new avenue in the future to mitigate cellular migration in gliomas.
Source: Molecular Cancer - July 15, 2013 Category: Cancer & Oncology Authors: Leroi DeSouzaAjay MattaZia KarimJoydeep MukherjeeX WangOlga KrakovskaGelareh ZadehAbhijit GuhaKW Siu Source Type: research