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Source: BMC Cancer
Therapy: Neoadjuvant Therapy
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Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy
Background:
Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemotherapy-induced MRP1 expression Notch in breast cancers, and whether this pathway can be manipulated with an inhibitor of Notch activity.
Methods:
MRP1 and Notch1 were investigated in 29 patients treated with neoadjuvant chemotherapy (NAC) for breast cancer, using immunohistochemistry on matched biopsy (pre-N...
Source: BMC Cancer - September 11, 2015 Category: Cancer & Oncology Authors: Baek KimSam StephenAndrew HanbyKieran HorganSarah PerryJulie RichardsonElizabeth RoundhillElizabeth ValleleyEldo VergheseBethany WilliamsJames ThorneThomas Hughes Source Type: research
