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Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
Background: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal function. Depleted intra-tumoral ascorbic acid may thus play a role in the loss of HIF-1α regulation in melanoma. These studies assess the ability of ascorbic acid to reduce HIF-1α protein and transcriptional activity in metastatic melanoma and reduce its invasive potential. Methods: HIF-1α protein was evaluated by wester...
Source: BMC Cancer - November 7, 2015 Category: Cancer & Oncology Authors: Sarah MilesAdam FischerSandeep JoshiRichard Niles Source Type: research

Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes
Conclusions: Our results indicate that the metabolic defects introduced by siRNA silencing of metabolic enzymes TKT or AK2 may be compensated by alternative feedback metabolic mechanisms, suggesting that cancer cells may overcome single defective pathways through secondary metabolic network adaptations. The highly robust nature of oral cancer cell metabolism implies that a systematic medical approach targeting multiple metabolic pathways may be needed to accomplish the continued improvement of cancer treatment.
Source: BMC Cancer - March 25, 2014 Category: Cancer & Oncology Authors: Min ZhangYang ChaiJeffrey BrumbaughXiaojun LiuRamin RabiiSizhe FengKaori MisunoDiana MessadiShen Hu Source Type: research