• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells.
Abstract β-Cell swelling induces membrane depolarization, which has been suggested to be caused at least partly by the activation of cation channels. Here, we show the identification of the cation channels. In isolated mouse pancreatic β-cells, the exposure to 30% hypotonic solution elicited an increase in cytosolic Ca2+ concentration ([Ca2+]c). The [Ca2+]c elevation was partially inhibited by ruthenium red, a blocker of several Ca2+-permeable channels including transient receptor potential vanilloid receptors (TRPV), and by nicardipine, but not by the depletion of intracellular Ca2+ stores with thapsigargin and...
Source: Am J Physiol Cell Ph... - January 16, 2019 Category: Cytology Authors: Sawatani T, Kaneko YK, Doutsu I, Ogawa A, Ishikawa T Tags: Am J Physiol Cell Physiol Source Type: research